MAML3
MAML3 (Mastermind Like Transcriptional Coactivator 3) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML1.
Full Name
MASTERMIND LIKE TRANSCRIPTIONAL COACTIVATOR 3
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Biological Process
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription of Notch receptor targetManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription of Notch receptor targetManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus speckle
Nuclear, in a punctate manner.
Nuclear, in a punctate manner.
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Anti-MAML3 antibodies
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Target: MAML3
Host: Mouse
Specificity: Human
Clone: CBFYM-1356
Application*: WB
Target: MAML3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1355
Application*: DB
Target: MAML3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MAML3/1303
Application*: F, P, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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