Rabbit Anti-MAOA Recombinant Antibody (
4C11) (V2LY-0725-LY1114)

Name: Rabbit Anti-MAOA Recombinant Antibody (4C11)
SKU: V2LY-0725-LY1114
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-MAOA Recombinant Antibody (4C11) (V2LY-0725-LY1114) in IHC

IHC image of V2LY-0725-LY1114 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Rabbit Anti-MAOA Recombinant Antibody (4C11) (V2LY-0725-LY1114) in IHC

IHC image of V2LY-0725-LY1114 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Rabbit Anti-MAOA Recombinant Antibody (4C11) (V2LY-0725-LY1114) in IF

Immunofluorescence staining of HepG2 Cells with V2LY-0725-LY1114 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

4C11

Application

ELISA, IHC, IF

Immunogen

A synthesized peptide derived from human Monoamine Oxidase A.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:50-1:200
IF	1:20-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MONOAMINE OXIDASE A

Entrez Gene ID

4128

UniProt ID

P21397

Function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519).
Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519).
Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).

Biological Process

Cellular biogenic amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Neurotransmitter catabolic processIEA:UniProtKB-KW
Positive regulation of signal transductionIEA:Ensembl

Cellular Location

Mitochondrion outer membrane

Involvement in disease

Brunner syndrome (BRNRS):
A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Topology

Cytoplasmic: 1-497
Helical: 498-518
Lumenal: 519-527

Han, H., Li, H., Ma, Y., Zhao, Z., An, Q., Zhao, J., & Shi, C. (2023). Monoamine oxidase A (MAOA): A promising target for prostate cancer therapy. Cancer Letters, 216188.

Pueyo, N., Navarro, J. B., Fatjó-Vilas, M., de la Osa, N., Penelo, E., Fañanás, L., & Ezpeleta, L. (2021). Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers. The European Journal of Psychiatry, 35(4), 225-233.

Wang, X., Li, B., Kim, Y. J., Wang, Y. C., Li, Z., Yu, J., ... & Yang, L. (2021). Targeting monoamine oxidase A for T cell–based cancer immunotherapy. Science immunology, 6(59), eabh2383.

Peters, T. M., Lammerts van Bueren, I., Geurtz, B. P., Coene, K. L., de Leeuw, N., Brunner, H. G., ... & Verbeek, M. M. (2021). Monoamine oxidase A activity in fibroblasts as a functional confirmation of MAOA variants. JIMD reports, 58(1), 114-121.

Schiele, M. A., Thiel, C., Deckert, J., Zaudig, M., Berberich, G., & Domschke, K. (2020). Monoamine oxidase A hypomethylation in obsessive-compulsive disorder: reversibility by successful psychotherapy?. International Journal of Neuropsychopharmacology, 23(5), 319-323.

Checknita, D., Bendre, M., Ekström, T. J., Comasco, E., Tiihonen, J., Hodgins, S., & Nilsson, K. W. (2020). Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour. Behavioural brain research, 382, 112476.

Kolla, N. J., & Bortolato, M. (2020). The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men. Progress in neurobiology, 194, 101875.

Gaur, S., Gross, M. E., Liao, C. P., Qian, B., & Shih, J. C. (2019). Effect of Monoamine oxidase A (MAOA) inhibitors on androgen‐sensitive and castration‐resistant prostate cancer cells. The Prostate, 79(6), 667-677.

Byrd, A. L., Manuck, S. B., Hawes, S. W., Vebares, T. J., Nimgaonkar, V., Chowdari, K. V., ... & Stepp, S. D. (2019). The interaction between monoamine oxidase A (MAOA) and childhood maltreatment as a predictor of personality pathology in females: Emotional reactivity as a potential mediating mechanism. Development and psychopathology, 31(1), 361-377.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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