MAOA

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Full Name

MONOAMINE OXIDASE A

Function

Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519).
Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519).
Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).

Biological Process

Cellular biogenic amine metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Dopamine catabolic processManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Neurotransmitter catabolic processIEA:UniProtKB-KW
Positive regulation of signal transductionIEA:Ensembl

Cellular Location

Mitochondrion outer membrane

Involvement in disease

Brunner syndrome (BRNRS):
A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Topology

Cytoplasmic: 1-497
Helical: 498-518
Lumenal: 519-527