Mouse Anti-MAP1A Recombinant Antibody (CBFYM-1377) (CBMAB-M1536-FY)

Name: Mouse Anti-MAP1A Recombinant Antibody (CBFYM-1377)
SKU: CBMAB-M1536-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1377

Application

IHC-Fr, IHC-P, WB

Immunogen

Rat brain microtubule-associated proteins (MAPs)

Specificity

Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MICROTUBULE ASSOCIATED PROTEIN 1A

Introduction

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.

Entrez Gene ID

25152

UniProt ID

P34926

Alternative Names

Microtubule Associated Protein 1A; Proliferation-Related Protein P80; MAP-1A; MAP1L; Microtubule-Associated Protein 1A; EC 2.7.2.8; EC 6.3.4.5; MTAP1A

Function

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Biological Process

Anterograde axonal protein transportISS:ARUK-UCL
Associative learningISS:ARUK-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
MemoryISS:ARUK-UCL
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processISS:ARUK-UCL
Negative regulation of protein localization to microtubuleISS:ARUK-UCL
Neuron cellular homeostasisISS:ARUK-UCL
Neuron projection maintenanceISS:ARUK-UCL
Positive regulation of protein localizationISS:ARUK-UCL
Positive regulation of protein localization to cell surfaceISS:ARUK-UCL
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic plasticityISS:ARUK-UCL
Retrograde axonal protein transportISS:ARUK-UCL
Voluntary musculoskeletal movementISS:ARUK-UCL

Cellular Location

Cytoplasm, cytoskeleton

PTM

Phosphorylated by CSNK1D.
LC2 is generated from MAP1A by proteolytic processing.

Lyu, X., Qiang, Y., Zhang, B., Xu, W., Cui, Y., & Ma, L. (2022). Identification of immuno-infiltrating MAP1A as a prognosis-related biomarker for bladder cancer and its ceRNA network construction. Frontiers in Oncology, 12, 1016542.

Hallam, R. D., Buchner-Duby, B., Stykel, M. G., Coackley, C. L., & Ryan, S. D. (2022). Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines. Journal of Neuroscience, 42(50), 9473-9487.

FAN, J., JIANG, Y., ZHANG, J., & BAI, X. (2019). Expression of MAP1A in bladder cancer and its correlation with clinicopathological features. Practical Oncology Journal, 525-530.

Fadiel, A., Nair, V. S., Aceto, P., & Naftolin, F. (2019). Identification of cancer specific protein 80 (CSP-80), a novel 80 kDa MAP1a-like protein in ovarian carcinoma cells. Cancer Research, 79(13_Supplement), 4296-4296.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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