MAP1A

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.

Full Name

MICROTUBULE ASSOCIATED PROTEIN 1A

Function

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Biological Process

Anterograde axonal protein transportISS:ARUK-UCL
Associative learningISS:ARUK-UCL
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
MemoryISS:ARUK-UCL
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processISS:ARUK-UCL
Negative regulation of protein localization to microtubuleISS:ARUK-UCL
Neuron cellular homeostasisISS:ARUK-UCL
Neuron projection maintenanceISS:ARUK-UCL
Positive regulation of protein localizationISS:ARUK-UCL
Positive regulation of protein localization to cell surfaceISS:ARUK-UCL
Regulation of microtubule depolymerizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic plasticityISS:ARUK-UCL
Retrograde axonal protein transportISS:ARUK-UCL
Voluntary musculoskeletal movementISS:ARUK-UCL

Cellular Location

Cytoplasm, cytoskeleton

PTM

Phosphorylated by CSNK1D.
LC2 is generated from MAP1A by proteolytic processing.