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Mouse Anti-MAP2 Recombinant Antibody (CBFYM-1396) (CBMAB-M1556-FY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBFYM-1396
Application
WB, IF, IHC
Specificity
Cattle, Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Microtubule Associated Protein 2
Introduction
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Entrez Gene ID
Human4133
Mouse17756
Rat25595
Cattle281294
UniProt ID
HumanP11137
MouseP20357
RatP15146
Alternative Names
Microtubule Associated Protein 2; MAP-2; Microtubule-Associated Protein 2; MAP2A; MAP2B; MAP2C
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Biological Process
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Dendrite developmentManual Assertion Based On ExperimentTAS:ARUK-UCL
Dendrite morphogenesisManual Assertion Based On ExperimentIEP:DFLAT
Microtubule bundle formationIEA:InterPro
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of axon extensionISS:ARUK-UCL
Negative regulation of microtubule bindingISS:ARUK-UCL
Negative regulation of microtubule polymerizationISS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Positive regulation of anterograde dense core granule transportISS:ARUK-UCL
Positive regulation of anterograde synaptic vesicle transportISS:ARUK-UCL
Regulation of microtubule polymerizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of organelle transport along microtubuleISS:ARUK-UCL
Regulation of protein localizationISS:ARUK-UCL
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, dendrite
PTM
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Nishida, K., Matsumura, K., Tamura, M., Nakamichi, T., Shimamori, K., Kuragano, M., ... & Tokuraku, K. (2023). Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules’ physical properties and neurite morphology. Scientific Reports, 13(1), 8870.

Yang, L., Xu, X., & Zheng, J. (2020). Microtubule-associated protein 2 knockdown sensitizes glioma cells to vincristine treatment. Neuroreport, 31(3), 197-204.

Avdoshina, V., Mahoney, M., Gilmore, S. F., Wenzel, E. D., Anderson, A., Letendre, S. L., ... & Mocchetti, I. (2020). HIV influences microtubule associated protein-2: potential marker of HIV-associated neurocognitive disorders. AIDS (London, England), 34(7), 979.

Kim, Y., Jang, Y. N., Kim, J. Y., Kim, N., Noh, S., Kim, H., ... & Lee, K. J. (2020). Microtubule‐associated protein 2 mediates induction of long‐term potentiation in hippocampal neurons. The FASEB Journal, 34(5), 6965-6983.

Le Large, T. Y. S., El Hassouni, B., Funel, N., Kok, B., Piersma, S. R., Pham, T. V., ... & Giovannetti, E. (2019). Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment. Therapeutic advances in medical oncology, 11, 1758835919841233.

McKinney, B. C., MacDonald, M. L., Newman, J. T., Shelton, M. A., DeGiosio, R. A., Kelly, R. M., ... & Sweet, R. A. (2019). Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia. Neuropsychopharmacology, 44(6), 1055-1061.

Bora, G., Sucularli, C., Hensel, N., Claus, P., & Yurter, H. (2019). Investigations of microtubule-associated protein 2 gene expression in spinal muscular atrophy. Journal of Pediatric Research, 6(2).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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