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MAP2

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Full Name
Microtubule Associated Protein 2
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Biological Process
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Dendrite developmentManual Assertion Based On ExperimentTAS:ARUK-UCL
Dendrite morphogenesisManual Assertion Based On ExperimentIEP:DFLAT
Microtubule bundle formationIEA:InterPro
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of axon extensionISS:ARUK-UCL
Negative regulation of microtubule bindingISS:ARUK-UCL
Negative regulation of microtubule polymerizationISS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Positive regulation of anterograde dense core granule transportISS:ARUK-UCL
Positive regulation of anterograde synaptic vesicle transportISS:ARUK-UCL
Regulation of microtubule polymerizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of organelle transport along microtubuleISS:ARUK-UCL
Regulation of protein localizationISS:ARUK-UCL
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, dendrite
PTM
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Anti-MAP2 antibodies

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Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1401
Application*: E, F, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYM-1399
Application*: IH, IC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1398
Application*: E, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-1397
Application*: WB, IP, IC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-1410
Application*: IF, C, P, IP, WB
Target: MAP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYM-1409
Application*: WB, IP, IF
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBFYM-1394
Application*: P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYM-0551
Application*: IH, WB
Target: MAP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-1408
Application*: P
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Mouse
Clone: CBFYM-1407
Application*: IC, P, C, E, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYM-1406
Application*: E, F, IC, IF, IH, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBFYM-1405
Application*: IH, P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYM-1403
Application*: IC, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0061
Application*: WB, P, IF
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Cattle
Clone: CBFYM-0169
Application*: WB, IH, IF
Target: MAP2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Cattle
Clone: CBFYM-0180
Application*: IC, IF, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Human, Mouse, Quail, Rat, Frog
Clone: CBFYM-0239
Application*: C, IF, WB, P
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Chicken, Cattle, Human, Quail
Clone: CBFYM-0325
Application*: WB, IP, P, C, IC, IF
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Cat, Mouse, Pig, Rat
Clone: CBFYM-0374
Application*: IC, IF, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBFYM-0548
Application*: IF, IH, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0549
Application*: IH, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBFYM-0550
Application*: E, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 1D7-B9-C8-F6
Application*: WB, IP, IC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB379A
Application*: ELISA, IHC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Cattle, Mouse, Rat, Pig
Clone: CB416A
Application*: ELISA, WB, ICC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Rat
Clone: CBFYM-1396
Application*: WB, IF, IH
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Human, Mouse, Pig
Clone: CBFYM-1395
Application*: E, IC, C, P, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Avian, Human, Mouse, Rat, Frog, Guinea pig
Clone: AP18
Application*: IF, IC, P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Rat, Human
Clone: AP20
Application*: IF, IC, P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Chicken, Cattle, Human, Quail
Clone: HM-2
Application*: IC, IF, C, P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Cat, Pig
Clone: MT-01
Application*: IC, IP, IF, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Mouse, Rat, Frog, Zebrafish, Quail, Salamander
Clone: AP-20
Application*: IC, IF, C, P, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: MP-2
Application*: ELISA, WB, IHC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A986
Application*: IF, IHC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A987
Application*: IHC, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A988
Application*: ELISA, IHC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: A989
Application*: ELISA, ICC, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A990
Application*: IHC
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A991
Application*: ICC, IP, WB
Target: MAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: A992
Application*: ICC, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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