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Mouse Anti-MAP3K14 Recombinant Antibody (CBT4290) (V2LY-0625-LY1243)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4290
Antibody Isotype
IgG1
Application
IHC, FC

Basic Information

Immunogen
Purified recombinant fragment of human MAP3K14 (AA: 769-947) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14
Entrez Gene ID
9020
UniProt ID
Q99558
Function
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
Biological Process
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
I-kappaB kinase/NF-kappaB signalingISS:UniProtKB
Immune responseISS:UniProtKB
NIK/NF-kappaB signalingTAS:Reactome
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
PTM
Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
More Infomation

Hong, Y., Heo, J., Kang, S., Vu, T. H., Lillehoj, H. S., & Hong, Y. H. (2023). Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14. Animal Bioscience, 36(6), 851.

Cormier, F., Housni, S., Dumont, F., Villard, M., Cochand-Priollet, B., Mercier-Nomé, F., ... & Groussin, L. (2023). NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK. Oncogenesis, 12(1), 55.

Zhang, J., He, L., Li, Q., Gao, J., Zhang, E., & Feng, H. (2023). EGR1 knockdown confers protection against ferroptosis and ameliorates intervertebral disc cartilage degeneration by inactivating the MAP3K14/NF-κB axis. Genomics, 115(5), 110683.

Huang, Q., Liu, Y., Qiu, M., Lin, Q., Wei, X., Zhou, Z., ... & Yu, H. (2022). Potentially functional variants of MAP3K14 in the NF-κB signaling pathway genes predict survival of HBV-related hepatocellular carcinoma patients. Frontiers in Oncology, 12, 990160.

Vesting, A. J., Jais, A., Klemm, P., Steuernagel, L., Wienand, P., Fog-Tonnesen, M., ... & Wunderlich, F. T. (2022). NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism, 66, 101626.

Hamdan, T. A., Bhat, H., Cham, L. B., Adomati, T., Lang, J., Li, F., ... & Lang, K. S. (2020). Map3k14 as a regulator of innate and adaptive immune response during acute viral infection. Pathogens, 9(2), 96.

Lian, Y., Hu, Y., Gan, L., Huo, Y. N., Luo, H. Y., & Wang, X. Z. (2019). Ssc-novel-miR-106-5p reduces lipopolysaccharide-induced inflammatory response in porcine endometrial epithelial cells by inhibiting the expression of the target gene mitogen-activated protein kinase kinase kinase 14 (MAP3K14). Reproduction, Fertility and Development, 31(10), 1616-1627.

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For research use only. Not intended for any clinical use.

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