Human Recombinant MAP3K14, Active protein, GST Tag (V2LY-0526-LY5432)

Name: Human Recombinant MAP3K14, Active protein, GST Tag
SKU: V2LY-0526-LY5432
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MAP3K14, Active protein, GST Tag consist of Amino Acid: 325-end and predicts a molecular mass of 108 kDa.

Molecule Mass

108 kDa

Sequence

Amino Acid: 325-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 14

Function

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Biological Process

Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
I-kappaB kinase/NF-kappaB signalingISS:UniProtKB
Immune responseISS:UniProtKB
NIK/NF-kappaB signalingTAS:Reactome
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm

PTM

Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.

Hong, Y., Heo, J., Kang, S., Vu, T. H., Lillehoj, H. S., & Hong, Y. H. (2023). Exosome-mediated delivery of gga-miR-20a-5p regulates immune response of chicken macrophages by targeting IFNGR2, MAPK1, MAP3K5, and MAP3K14. Animal Bioscience, 36(6), 851.

Cormier, F., Housni, S., Dumont, F., Villard, M., Cochand-Priollet, B., Mercier-Nomé, F., ... & Groussin, L. (2023). NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK. Oncogenesis, 12(1), 55.

Zhang, J., He, L., Li, Q., Gao, J., Zhang, E., & Feng, H. (2023). EGR1 knockdown confers protection against ferroptosis and ameliorates intervertebral disc cartilage degeneration by inactivating the MAP3K14/NF-κB axis. Genomics, 115(5), 110683.

Huang, Q., Liu, Y., Qiu, M., Lin, Q., Wei, X., Zhou, Z., ... & Yu, H. (2022). Potentially functional variants of MAP3K14 in the NF-κB signaling pathway genes predict survival of HBV-related hepatocellular carcinoma patients. Frontiers in Oncology, 12, 990160.

Vesting, A. J., Jais, A., Klemm, P., Steuernagel, L., Wienand, P., Fog-Tonnesen, M., ... & Wunderlich, F. T. (2022). NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Molecular Metabolism, 66, 101626.

Hamdan, T. A., Bhat, H., Cham, L. B., Adomati, T., Lang, J., Li, F., ... & Lang, K. S. (2020). Map3k14 as a regulator of innate and adaptive immune response during acute viral infection. Pathogens, 9(2), 96.

Lian, Y., Hu, Y., Gan, L., Huo, Y. N., Luo, H. Y., & Wang, X. Z. (2019). Ssc-novel-miR-106-5p reduces lipopolysaccharide-induced inflammatory response in porcine endometrial epithelial cells by inhibiting the expression of the target gene mitogen-activated protein kinase kinase kinase 14 (MAP3K14). Reproduction, Fertility and Development, 31(10), 1616-1627.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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