Mouse Anti-MAP3K15 Recombinant Antibody (1H7) (CBMAB-A5207-LY)

The product is antibody recognizes MAP3K15. The antibody 1H7 immunoassay techniques such as: WB, ELISA.
See all MAP3K15 antibodies

Published Data

Fig.1 The activation of MAPKs due to the overexpression of ASK constructs was analysed by immunoblotting

Fig.2 Immunohistochemical staining of ASK3 in the kidney.

Summary

Host Animal

Mouse

Specificity

Human

Clone

1H7

Antibody Isotype

IgG2b, κ

Application

WB, ELISA

Basic Information

Immunogen

MAP3K15 (NP_001001671, 691 a.a. ~ 786 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

mitogen-activated protein kinase kinase kinase 15

Entrez Gene ID

389840

UniProt ID

Q6ZN16

Alternative Names

FLJ16518; bA723P2.3

Function

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.

References

Nag, A., Dhindsa, R. S., Mitchell, J., Vasavda, C., Harper, A. R., Vitsios, D., ... & Petrovski, S. (2022). Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes. Science advances, 8(46), eadd5430.

Zhou, R., Wang, Q., Hou, J., Wang, D., & Liang, Y. (2022). Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus. Hereditas, 159(1), 1-7.

Chen, Z., Kong, H., Cai, Z., Chen, K., Wu, B., Li, H., ... & Shen, H. (2021). Identification of MAP3K15 as a potential prognostic biomarker and correlation with immune infiltrates in osteosarcoma. Annals of Translational Medicine, 9(14).

Nag, A., Dhindsa, R. S., Harper, A. R., Vitsios, D., Ahnmark, A., Bilican, B., ... & Petrovski, S. (2021). Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes. medRxiv, 2021-11.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MAP3K15 (AA 979-1313 ) Recombinant Antibody (CBFYM-1515)

Mouse Anti-MAP3K15 Recombinant Antibody (CBFYM-1517)

Mouse Anti-MAP3K15 Recombinant Antibody (CBFYM-0558)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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