Mouse Anti-MAP3K15 (AA 979-1313 ) Recombinant Antibody (CBFYM-1515) (CBMAB-M1678-FY)

This product is mouse antibody that recognizes MAP3K15. The antibody CBFYM-1515 can be used for immunoassay techniques such as: WB.
See all MAP3K15 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-1515

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Human recombinant protein fragment corresponding to amino acids 979-1313 of human MAP3K15 (NP_001001671) produced in E.coli

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 979-1313

Target

Full Name

mitogen-activated protein kinase kinase kinase 15

Introduction

The protein encoded by this gene is a member of the mitogen-activated protein kinase family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase phosphorylates and activates a specific MAPK kinase, which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses.

Entrez Gene ID

389840

UniProt ID

Q6ZN16

Alternative Names

Mitogen-Activated Protein Kinase Kinase Kinase 15; Apoptosis Signal-Regulating Kinase 3; MAPK/ERK Kinase Kinase 15; MEK Kinase 15; EC 2.7.11.25; MEKK 15; ASK3; BA723P2.3; EC 2.7.11

Function

May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.

References

Nag, A., Dhindsa, R. S., Mitchell, J., Vasavda, C., Harper, A. R., Vitsios, D., ... & Petrovski, S. (2022). Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes. Science advances, 8(46), eadd5430.

Zhou, R., Wang, Q., Hou, J., Wang, D., & Liang, Y. (2022). Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus. Hereditas, 159(1), 1-7.

Chen, Z., Kong, H., Cai, Z., Chen, K., Wu, B., Li, H., ... & Shen, H. (2021). Identification of MAP3K15 as a potential prognostic biomarker and correlation with immune infiltrates in osteosarcoma. Annals of Translational Medicine, 9(14).

Nag, A., Dhindsa, R. S., Harper, A. R., Vitsios, D., Ahnmark, A., Bilican, B., ... & Petrovski, S. (2021). Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes. medRxiv, 2021-11.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-MAP3K15 Recombinant Antibody (1H7)

Mouse Anti-MAP3K15 Recombinant Antibody (CBFYM-1517)

Mouse Anti-MAP3K15 Recombinant Antibody (CBFYM-0558)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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