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Rabbit Anti-MAP3K20 Recombinant Antibody (CBWJZ-012) (CBMAB-Z0019-WJ)

This product is a rabbit antibody that recognizes MAP3K20. The antibody CBWJZ-012 can be used for immunoassay techniques such as: WB, IHC-P, FC, IF.
See all MAP3K20 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJZ-012
Antibody Isotype
IgG
Application
WB, IHC-P, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Mitogen-Activated Protein Kinase Kinase Kinase 20
Introduction
MAP3K20 (Mitogen-Activated Protein Kinase Kinase Kinase 20) is a Protein Coding gene encodes a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Diseases associated with MAP3K20 include Split-Foot Malformation With Mesoaxial Polydactyly and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion. Among its related pathways are MAPK signaling pathway and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. An important paralog of this gene is MAP3K21.
Entrez Gene ID
Human51776
Mouse65964
Rat311743
UniProt ID
HumanQ9NYL2
MouseQ9ESL4
RatD4AE17
Alternative Names
pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
Function
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381).
Involved in limb development (PubMed:26755636).
Isoform 1
Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425).
May have role in neoplastic cell transformation and cancer development (PubMed:15172994).
Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
Biological Process
Cell cycleIEA:UniProtKB-KW
Cell death1 PublicationNAS:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cellular response to gamma radiationManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organizationIEA:Ensembl
DNA damage checkpoint signalingManual Assertion Based On ExperimentIMP:UniProtKB
Embryonic digit morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
p38MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Translocates to the nucleus upon ultraviolet B irradiation.
Involvement in disease
Split-foot malformation with mesoaxial polydactyly (SFMMP):
An autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss.
Myopathy, centronuclear, 6, with fiber-type disproportion (CNM6):
A form of centronuclear myopathy, a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. CNM6 is an autosomal recessive, slowly progressive form with onset in infancy or early childhood.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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