Human Recombinant ZAK, Active protein, GST Tag (V2LY-0526-LY7694)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Involved in limb development (PubMed:26755636).
Isoform 1
Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425).
May have role in neoplastic cell transformation and cancer development (PubMed:15172994).
Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
Cell death1 PublicationNAS:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cellular response to gamma radiationManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organizationIEA:Ensembl
DNA damage checkpoint signalingManual Assertion Based On ExperimentIMP:UniProtKB
Embryonic digit morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
p38MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of mitotic DNA damage checkpointManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Stress-activated MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus
Translocates to the nucleus upon ultraviolet B irradiation.
An autosomal recessive disorder characterized by a split-foot defect, mesoaxial polydactyly, nail abnormalities of the hands, and sensorineural hearing loss.
Myopathy, centronuclear, 6, with fiber-type disproportion (CNM6):
A form of centronuclear myopathy, a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. CNM6 is an autosomal recessive, slowly progressive form with onset in infancy or early childhood.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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