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Rabbit Anti-MAP3K9 Recombinant Antibody (CBFYM-1543) (CBMAB-M1707-FY)

This product is rabbit antibody that recognizes MAP3K9. The antibody CBFYM-1543 can be used for immunoassay techniques such as: WB, IP.
See all MAP3K9 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYM-1543
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitogen-Activated Protein Kinase Kinase Kinase 9
Introduction
MAP3K9 is a Protein Coding gene. Diseases associated with MAP3K9 include Retroperitoneum Carcinoma and Retroperitoneal Neuroblastoma. Among its related pathways are NFAT and Cardiac Hypertrophy and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is MAP3K10.
Entrez Gene ID
Human4293
Mouse338372
UniProt ID
HumanP80192
MouseQ3U1V8
Alternative Names
Mitogen-Activated Protein Kinase Kinase Kinase 9; EC 2.7.11.25; PRKE1; MLK1; Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity); Mixed Lineage Kinase 1; EC 2.7.11; MEKK9
Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Positive regulation of apoptotic processIEA:Ensembl
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
PTM
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.

Jun, L., Xuhong, L., & Hui, L. (2023). Circ_SIPA1L1 promotes osteosarcoma progression via miR-379-5p/MAP3K9 axis. Cancer Biotherapy & Radiopharmaceuticals, 38(9), 604-618.

Liu, M., Xiao, B., Zhu, Y., Chen, M., Huang, J., Guo, H., & Wang, F. (2023). MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9. European journal of medical research, 28(1), 264.

Zheng, J., Zhao, Z., Ren, H., Wang, Y., Meng, X., Zhang, W., ... & Lu, X. (2022). LncRNA HCG11 facilitates nasopharyngeal carcinoma progression through regulating miRNA-490-3p/MAP3K9 Axis. Frontiers in Oncology, 12, 872033.

Zhou, J. L., Deng, S., Fang, H. S., Peng, H., & Hu, Q. J. (2022). CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. International Immunopharmacology, 110, 109064.

Liang, L., Xu, W. Y., Shen, A., Cen, H. Y., Chen, Z. J., Tan, L., ... & Yu, X. Y. (2022). Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. Acta Pharmacologica Sinica, 43(11), 2946-2955.

Lu, X., Gan, Q., & Gan, C. (2021). Circular RNA circSEC24A promotes cutaneous squamous cell carcinoma progression by regulating miR-1193/MAP3K9 axis. OncoTargets and therapy, 653-666.

Ren, Q., Xiao, X., Leng, X., Zhang, Q., Zhou, X., Ren, Z., & Xiao, H. (2021). MicroRNA‑361‑5p induces hepatocellular carcinoma cell apoptosis and enhances drug sensitivity by targeting MAP3K9. Experimental and Therapeutic Medicine, 21(6), 1-8.

Wang, Y., Xie, C., Song, Y., Xiang, W., Peng, J., Han, L., ... & Guan, Y. (2021). miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis. Journal of Translational Medicine, 19(1), 223.

Abbasi, S. A., Baig, R. M., Ahmed, M. N., Ismail, M., Khan, R., Mehmood, H., & Mansoor, Q. (2021). MAP3K1 SNP rs889312 potential risk and MAP3K9 SNP rs11628333 menopause dependent association for breast cancer. Turkish Journal of Biochemistry, 47(4), 417-423.

Zhang, B. X., Yu, T., Yu, Z., & Yang, X. G. (2019). MicroRNA-148a regulates the MAPK/ERK signaling pathway and suppresses the development of esophagus squamous cell carcinoma via targeting MAP3K9. European Review for Medical & Pharmacological Sciences, 23(15).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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