Human Recombinant MAP3K9, Active protein, GST Tag (V2LY-0526-LY5446)

Name: Human Recombinant MAP3K9, Active protein, GST Tag
SKU: V2LY-0526-LY5446
Rating: 5 (1 reviews)

See all MAP3K9 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant MAP3K9, Active protein, GST Tag consist of Amino Acid: 1-433 and predicts a molecular mass of 77 kDa.

Molecule Mass

77 kDa

Sequence

Amino Acid: 1-433

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Mitogen-Activated Protein Kinase Kinase Kinase 9

Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Positive regulation of apoptotic processIEA:Ensembl
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

PTM

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. Autophosphorylation also occurs on Thr-304 and Ser-308.

Jun, L., Xuhong, L., & Hui, L. (2023). Circ_SIPA1L1 promotes osteosarcoma progression via miR-379-5p/MAP3K9 axis. Cancer Biotherapy & Radiopharmaceuticals, 38(9), 604-618.

Liu, M., Xiao, B., Zhu, Y., Chen, M., Huang, J., Guo, H., & Wang, F. (2023). MicroRNA-144-3p protects against chemotherapy-induced apoptosis of ovarian granulosa cells and activation of primordial follicles by targeting MAP3K9. European journal of medical research, 28(1), 264.

Zheng, J., Zhao, Z., Ren, H., Wang, Y., Meng, X., Zhang, W., ... & Lu, X. (2022). LncRNA HCG11 facilitates nasopharyngeal carcinoma progression through regulating miRNA-490-3p/MAP3K9 Axis. Frontiers in Oncology, 12, 872033.

Zhou, J. L., Deng, S., Fang, H. S., Peng, H., & Hu, Q. J. (2022). CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9. International Immunopharmacology, 110, 109064.

Liang, L., Xu, W. Y., Shen, A., Cen, H. Y., Chen, Z. J., Tan, L., ... & Yu, X. Y. (2022). Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. Acta Pharmacologica Sinica, 43(11), 2946-2955.

Lu, X., Gan, Q., & Gan, C. (2021). Circular RNA circSEC24A promotes cutaneous squamous cell carcinoma progression by regulating miR-1193/MAP3K9 axis. OncoTargets and therapy, 653-666.

Ren, Q., Xiao, X., Leng, X., Zhang, Q., Zhou, X., Ren, Z., & Xiao, H. (2021). MicroRNA‑361‑5p induces hepatocellular carcinoma cell apoptosis and enhances drug sensitivity by targeting MAP3K9. Experimental and Therapeutic Medicine, 21(6), 1-8.

Wang, Y., Xie, C., Song, Y., Xiang, W., Peng, J., Han, L., ... & Guan, Y. (2021). miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis. Journal of Translational Medicine, 19(1), 223.

Abbasi, S. A., Baig, R. M., Ahmed, M. N., Ismail, M., Khan, R., Mehmood, H., & Mansoor, Q. (2021). MAP3K1 SNP rs889312 potential risk and MAP3K9 SNP rs11628333 menopause dependent association for breast cancer. Turkish Journal of Biochemistry, 47(4), 417-423.

Zhang, B. X., Yu, T., Yu, Z., & Yang, X. G. (2019). MicroRNA-148a regulates the MAPK/ERK signaling pathway and suppresses the development of esophagus squamous cell carcinoma via targeting MAP3K9. European Review for Medical & Pharmacological Sciences, 23(15).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant MAP3K9, Active protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-MAP3K9 Recombinant Antibody (CBFYM-1543) (CAT#: CBMAB-M1707-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry