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Mouse Anti-MARCH1 Recombinant Antibody (CBFYM-0575) (CBMAB-M0704-FY)

This product is mouse antibody that recognizes MARCH1. The antibody CBFYM-0575 can be used for immunoassay techniques such as: ELISA.
See all MARCH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0575
Antibody Isotype
IgG2a, k
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
membrane-associated ring finger (C3HC4) 1
Introduction
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases. MARCH proteins add ubiquitin to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex class II molecules and other glycoproteins by directing them to the late endosomal/lysosomal compartment.
Entrez Gene ID
55016
UniProt ID
Q8TCQ1
Alternative Names
Membrane Associated Ring-CH-Type Finger 1; Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase; Membrane-Associated RING Finger Protein 1; RING-Type E3 Ubiquitin Transferase MARCH1; Membrane-Associated RING-CH Protein I; RING Finger Protein 171; MARCH-I
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Biological Process
Antigen processing and presentation of peptide antigen via MHC class II Source: UniProtKB
Immune response Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Endosome
Late endosome membrane
Early endosome membrane
Lysosome
Lysosome membrane
Golgi apparatus
trans-Golgi network membrane
Other locations
Cytoplasmic vesicle membrane
PTM
Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins (By similarity).

Xu, Z., Liu, J., Liu, Z., & Zhang, H. (2022). MARCH1 as a novel immune-related prognostic biomarker that shapes an inflamed tumor microenvironment in lung adenocarcinoma. Frontiers in Oncology, 12, 1008753.

Villalón-Letelier, F., Farrukee, R., Londrigan, S. L., Brooks, A. G., & Reading, P. C. (2022). Isoforms of human MARCH1 differ in ability to restrict influenza A viruses due to differences in their N terminal cytoplasmic domain. Viruses, 14(11), 2549.

He, X., Liu, J., Xiao, X., Zhang, S., Wang, X., Liu, J., ... & Yang, P. (2022). Targeting psychological stress-steroid-MARCH1 signaling pathway promotes the efficacy of specific allergen immunotherapy. Theranostics, 12(18), 7717.

Castellanos, C. A., Ren, X., Gonzalez, S. L., Li, H. K., Schroeder, A. W., Liang, H. E., ... & Shin, J. S. (2021). Lymph node–resident dendritic cells drive TH2 cell development involving MARCH1. Science immunology, 6(64), eabh0707.

Yang, W., Su, J., Li, M., Li, T., Wang, X., Zhao, M., & Hu, X. (2021). Myricetin induces autophagy and cell cycle arrest of HCC by inhibiting MARCH1-regulated Stat3 and p38 MAPK signaling pathways. Frontiers in Pharmacology, 12, 709526.

Wu, J., Xia, L., Yao, X., Yu, X., Tumas, K. C., Sun, W., ... & Su, X. Z. (2020). The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation. Proceedings of the National Academy of Sciences, 117(28), 16567-16578.

Dai, H., Li, M., Yang, W., Sun, X., Wang, P., Wang, X., ... & Zhao, M. (2020). Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. Aging (Albany NY), 12(12), 11717.

Xie, L., Dai, H., Li, M., Yang, W., Yu, G., Wang, X., ... & Zhao, M. (2019). MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K‐AKT‐β‐catenin pathways. Journal of cellular and molecular medicine, 23(5), 3386-3401.

Xie, L., Li, M., Liu, D., Wang, X., Wang, P., Dai, H., ... & Zhao, M. (2019). Secalonic acid-F, a novel mycotoxin, represses the progression of hepatocellular carcinoma via MARCH1 regulation of the PI3K/AKT/β-catenin signaling pathway. Molecules, 24(3), 393.

Kang, Z., Jiang, E., Wang, K., Pan, C., Chen, H., Yan, H., ... & Lan, X. (2019). Goat membrane associated ring-CH-type finger 1 (MARCH1) mRNA expression and association with litter size. Theriogenology, 128, 8-16.

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For research use only. Not intended for any clinical use.

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