Mouse Anti-MARK3 Recombinant Antibody (1A10) (CBMAB-C3505-LY)

Name: Mouse Anti-MARK3 Recombinant Antibody (1A10)
SKU: CBMAB-C3505-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A10

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MAP/microtubule affinity-regulating kinase 3

Introduction

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Entrez Gene ID

4140

UniProt ID

P27448

Alternative Names

Microtubule Affinity Regulating Kinase 3; MAP/Microtubule Affinity-Regulating Kinase 3; Serine/Threonine-Protein Kinase P78; Cdc25C-Associated Protein Kinase 1; Ser/Thr Protein Kinase PAR-1; Protein Kinase STK10; ELKL Motif Kinase 2; EC 2.7.11.1; C-TAK1;

Function

Serine/threonine-protein kinase (PubMed:23666762).

Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).

Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613).

Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

Biological Process

Intracellular signal transduction Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Negative regulation of hippo signaling Source: UniProtKB
Peptidyl-serine autophosphorylation Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of protein binding Source: ARUK-UCL
Protein phosphorylation Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Cytoplasm and Cytosol
Cytoplasm
Other locations
Dendrite

Involvement in disease

Visual impairment and progressive phthisis bulbi (VIPB):
An autosomal recessive, progressive disease characterized by poor vision at birth and development of bilateral phthisis bulbi by adulthood.

PTM

Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.

Wang, L., Liu, X., & Xia, Z. (2023). CircUBXN7 Impedes Apoptosis to Alleviate Myocardial Infarction Injury by Regulating the miR-582-3p/MARK3 Axis. Annals of Clinical & Laboratory Science, 53(2), 303-312.

Yang, J., Niu, H., Pang, S., Liu, M., Chen, F., Li, Z., ... & Huang, Y. (2023). MARK3 kinase: Regulation and physiologic roles. Cellular Signalling, 103, 110578.

Baqai, U., Kurimchak, A. M., Trachtenberg, I. V., Purwin, T. J., Haj, J. I., Han, A., ... & Aplin, A. E. (2023). Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma. Journal of Biological Chemistry, 299(12).

Mishima, T., Ohta, Y., Ohashi, K., & Mizuno, K. (2023). MARK3-mediated Slingshot-1 phosphorylation is essential for polarized lamellipodium formation. bioRxiv, 2023-10.

Machino, H., Kaneko, S., Komatsu, M., Ikawa, N., Asada, K., Nakato, R., ... & Hamamoto, R. (2022). The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Communications Biology, 5(1), 39.

Zhang, Q., Mesner, L. D., Calabrese, G. M., Dirckx, N., Li, Z., Verardo, A., ... & Clemens, T. L. (2021). Genomic variants within chromosome 14q32. 32 regulate bone mass through MARK3 signaling in osteoblasts. The Journal of Clinical Investigation, 131(7).

Li, F., Liu, Z., Sun, H., Li, C., Wang, W., Ye, L., ... & Wang, H. (2020). PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo. Acta Pharmaceutica Sinica B, 10(2), 289-300.

Jeon, T. E., & Jin, H. S. (2019). PDGFC, MARK3 and BCL2 Polymorphisms are Associated with Left Ventricular Hypertrophy in Korean Population. Biomedical Science Letters, 25(3), 237-246.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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