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MARK3

The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Full Name

MAP/microtubule affinity-regulating kinase 3

Function

Serine/threonine-protein kinase (PubMed:23666762).

Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).

Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613).

Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).

Biological Process

Intracellular signal transduction Source: GO_Central
Microtubule cytoskeleton organization Source: GO_Central
Negative regulation of hippo signaling Source: UniProtKB
Peptidyl-serine autophosphorylation Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of protein binding Source: ARUK-UCL
Protein phosphorylation Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Cytoplasm and Cytosol
Cytoplasm
Other locations
Dendrite

Involvement in disease

Visual impairment and progressive phthisis bulbi (VIPB):
An autosomal recessive, progressive disease characterized by poor vision at birth and development of bilateral phthisis bulbi by adulthood.

PTM

Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity.

Anti-MARK3 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-MARK3 Recombinant Antibody (CBCNC-659) (CBMAB-C3923-CN)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-659

Application*: P, IP, WB

Mouse Anti-MARK3 Recombinant Antibody (4H379) (CBMAB-C3922-CN)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: 4H379

Application*: IP, WB

Mouse Anti-MARK3 Recombinant Antibody (CBXC-2860) (CBMAB-C4753-CQ)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2860

Application*: P, WB

Mouse Anti-MARK3 (AA 473-729) Recombinant Antibody (CBYY-C2647) (CBMAB-C4088-YY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2647

Application*: P

Mouse Anti-MARK3 (AA 473-729) Recombinant Antibody (CBYY-C2646) (CBMAB-C4087-YY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C2646

Application*: WB

Mouse Anti-MARK3 (AA 473-729) Recombinant Antibody (CBFYC-2937) (CBMAB-C3013-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2937

Application*: WB

Mouse Anti-MARK3 Recombinant Antibody (CBFYC-2936) (CBMAB-C3012-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-2936

Application*: E, WB

Mouse Anti-MARK3 (C-terminus) Recombinant Antibody (CBFYM-1725) (CBMAB-M1892-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBFYM-1725

Application*: WB, IH, IP

Mouse Anti-MARK3 Recombinant Antibody (CBFYM-1724) (CBMAB-M1891-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYM-1724

Application*: E, F, IH, P, WB

Mouse Anti-MARK3 (AA 435-658) Recombinant Antibody (CBFYM-1723) (CBMAB-M1890-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYM-1723

Application*: E, F, IH, WB

Mouse Anti-MARK3 Recombinant Antibody (CBFYM-1722) (CBMAB-M1889-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-1722

Application*: WB, E, F, IF

Mouse Anti-MARK3 (AA 402-500) Recombinant Antibody (CBFYM-1721) (CBMAB-M1888-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYM-1721

Application*: E, WB

Mouse Anti-MARK3 (AA 473-729 ) Recombinant Antibody (CBFYM-1720) (CBMAB-M1887-FY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-1720

Application*: WB, IH

Mouse Anti-MARK3 Recombinant Antibody (3E11) (CBMAB-C5937-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3E11

Application*: P

Mouse Anti-MARK3 Recombinant Antibody (3D8) (CBMAB-C5904-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3D8

Application*: WB

Mouse Anti-MARK3 Recombinant Antibody (2G8) (CBMAB-C5223-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G8

Application*: P, WB

Mouse Anti-MARK3 Recombinant Antibody (2G12) (CBMAB-C5156-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G12

Application*: E, F, P, WB

Mouse Anti-MARK3 Recombinant Antibody (2A4) (CBMAB-C4614-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A4

Application*: WB

Mouse Anti-MARK3 Recombinant Antibody (1A10) (CBMAB-C3505-LY)

SDS

Target: MARK3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A10

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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