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Mouse Anti-MAS1 Recombinant Antibody (CBFYM-1735) (CBMAB-M1902-FY)

This product is mouse antibody that recognizes MAS1. The antibody CBFYM-1735 can be used for immunoassay techniques such as: ELISA, WB.
See all MAS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1735
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Immunogen
Partial peptide of Human MAS1
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAS1 PROTO-ONCOGENE, G PROTEIN-COUPLED RECEPTOR
Introduction
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin- and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-.
Entrez Gene ID
4142
UniProt ID
P04201
Alternative Names
MAS1 Proto-Oncogene, G Protein-Coupled Receptor; MAS1 Oncogene; MAS; Mas-Related G Protein-Coupled Receptor A; Proto-Oncogene Mas; MGRA
Function
Receptor for angiotensin 1-7 (By similarity).

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
Biological Process
Activation of NF-kappaB-inducing kinase activity Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Hippocampus development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Positive regulation of inositol phosphate biosynthetic process Source: Ensembl
Protein kinase C signaling Source: UniProtKB
Regulation of inflammatory response Source: Ensembl
Response to activity Source: Ensembl
Response to gonadotropin Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Spermatogenesis Source: Ensembl
Cellular Location
Plasma membrane
Cell membrane
Topology
Cytoplasmic: 1-36
Helical: 37-61
Extracellular: 62-65
Helical: 66-86
Cytoplasmic: 87-104
Helical: 105-128
Extracellular: 129-149
Helical: 150-172
Cytoplasmic: 173-185
Helical: 186-206
Extracellular: 207-224
Helical: 225-245
Cytoplasmic: 246-263
Helical: 264-284
Extracellular: 285-325
PTM
The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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