Mouse Anti-MAS1 Recombinant Antibody (CBFYM-1735) (CBMAB-M1902-FY)

Name: Mouse Anti-MAS1 Recombinant Antibody (CBFYM-1735)
SKU: CBMAB-M1902-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-1735

Application

ELISA, WB

Immunogen

Partial peptide of Human MAS1

Specificity

Human

Antibody Isotype

IgG1, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.25 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MAS1 PROTO-ONCOGENE, G PROTEIN-COUPLED RECEPTOR

Introduction

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin- and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-.

Entrez Gene ID

4142

UniProt ID

P04201

Alternative Names

MAS1 Proto-Oncogene, G Protein-Coupled Receptor; MAS1 Oncogene; MAS; Mas-Related G Protein-Coupled Receptor A; Proto-Oncogene Mas; MGRA

Function

Receptor for angiotensin 1-7 (By similarity).

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Biological Process

Activation of NF-kappaB-inducing kinase activity Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Hippocampus development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Positive regulation of inositol phosphate biosynthetic process Source: Ensembl
Protein kinase C signaling Source: UniProtKB
Regulation of inflammatory response Source: Ensembl
Response to activity Source: Ensembl
Response to gonadotropin Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Spermatogenesis Source: Ensembl

Cellular Location

Plasma membrane
Cell membrane

Topology

Cytoplasmic: 1-36
Helical: 37-61
Extracellular: 62-65
Helical: 66-86
Cytoplasmic: 87-104
Helical: 105-128
Extracellular: 129-149
Helical: 150-172
Cytoplasmic: 173-185
Helical: 186-206
Extracellular: 207-224
Helical: 225-245
Cytoplasmic: 246-263
Helical: 264-284
Extracellular: 285-325

PTM

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.

Kuriakose, J., Montezano, A. C., & Touyz, R. M. (2021). ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease. Clinical Science, 135(2), 387-407.

Domińska, K. (2020). Involvement of ACE2/Ang-(1-7)/MAS1 axis in the regulation of ovarian function in mammals. International Journal of Molecular Sciences, 21(13), 4572.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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