MAS1

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7).

Full Name

MAS1 PROTO-ONCOGENE, G PROTEIN-COUPLED RECEPTOR

Function

Receptor for angiotensin 1-7 (By similarity).

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Biological Process

Activation of NF-kappaB-inducing kinase activity Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Hippocampus development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of DNA replication Source: Ensembl
Positive regulation of inositol phosphate biosynthetic process Source: Ensembl
Protein kinase C signaling Source: UniProtKB
Regulation of inflammatory response Source: Ensembl
Response to activity Source: Ensembl
Response to gonadotropin Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Spermatogenesis Source: Ensembl

Cellular Location

Plasma membrane
Cell membrane

Topology

Cytoplasmic: 1-36
Helical: 37-61
Extracellular: 62-65
Helical: 66-86
Cytoplasmic: 87-104
Helical: 105-128
Extracellular: 129-149
Helical: 150-172
Cytoplasmic: 173-185
Helical: 186-206
Extracellular: 207-224
Helical: 225-245
Cytoplasmic: 246-263
Helical: 264-284
Extracellular: 285-325

PTM

The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells.