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Mouse Anti-MAT1A Recombinant Antibody (4D11) (CBMAB-A5315-LY)

The product is antibody recognizes MAT1A. The antibody 4D11 immunoassay techniques such as: WB, ELISA.
See all MAT1A antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MAT1A (AAH18359, 1 a.a. ~ 395 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
methionine adenosyltransferase I, alpha
Introduction
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq]
Entrez Gene ID
UniProt ID
Alternative Names
MAT; MATA1; SAMS; SAMS1
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Biological Process
Methionine catabolic process Source: UniProtKB
One-carbon metabolic process Source: UniProtKB-KW
Protein homotetramerization Source: UniProtKB
S-adenosylmethionine biosynthetic process Source: ComplexPortal
Cellular Location
Cytosol
Other locations
methionine adenosyltransferase complex
Involvement in disease
Methionine adenosyltransferase deficiency (MATD):
An inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity.
PTM
S-nitrosylation of Cys-120 inactivates the enzyme.
An intrachain disulfide bond can be formed. The protein structure shows that the relevant Cys residues are in a position that would permit formation of a disulfide bond.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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