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Mouse Anti-MAT2A (AA 1-395) Recombinant Antibody (CBFYM-1756) (CBMAB-M1924-FY)

This product is mouse antibody that recognizes MAT2A. The antibody CBFYM-1756 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all MAT2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1756
Antibody Isotype
IgG2b, k
Application
ELISA, IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-395 of human MAT2A expressed in E. coli (NP_005902)
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-395

Target

Full Name
METHIONINE ADENOSYLTRANSFERASE 2A
Introduction
The protein encoded by this gene catalyzes the production of S-adenosylmethionine from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
Entrez Gene ID
4144
UniProt ID
P31153
Alternative Names
Methionine Adenosyltransferase 2A; Methionine Adenosyltransferase II, Alpha; Methionine Adenosyltransferase 2; AdoMet Synthase 2; EC 2.5.1.6; MAT-II; MAT 2; MATA2
Function
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
One-carbon metabolic process Source: UniProtKB-KW
Protein heterooligomerization Source: UniProtKB
Protein hexamerization Source: UniProtKB
S-adenosylmethionine biosynthetic process Source: UniProtKB
Cellular Location
Cytosol
Other locations
methionine adenosyltransferase complex

Golbourn, B. J., Halbert, M. E., Halligan, K., Varadharajan, S., Krug, B., Mbah, N. E., ... & Agnihotri, S. (2022). Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome. Nature cancer, 3(5), 629-648.

Li, C., Gui, G., Zhang, L., Qin, A., Zhou, C., & Zha, X. (2022). Overview of methionine adenosyltransferase 2A (MAT2A) as an anticancer target: Structure, function, and inhibitors. Journal of Medicinal Chemistry, 65(14), 9531-9547.

Chen, Y. W., Du, Q. R., He, Y. J., Chen, W. S., Jiang, W. Y., Gui, Q., ... & Cheng, H. Y. (2021). Circ_0044516 regulates miR-136/MAT2A pathway to facilitate lung cancer development. Journal of immunology research, 2021.

Scarborough, A. M., Flaherty, J. N., Hunter, O. V., Liu, K., Kumar, A., Xing, C., ... & Conrad, N. K. (2021). SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. Elife, 10, e64930.

Chu, P. Y., Wu, H. J., Wang, S. M., Chen, P. M., Tang, F. Y., & Chiang, E. P. I. (2021). MAT2A localization and its independently prognostic relevance in breast cancer patients. International journal of molecular sciences, 22(10), 5382.

Konteatis, Z., Travins, J., Gross, S., Marjon, K., Barnett, A., Mandley, E., ... & Marks, K. M. (2021). Discovery of AG-270, a first-in-class oral MAT2A inhibitor for the treatment of tumors with homozygous MTAP deletion. Journal of Medicinal Chemistry, 64(8), 4430-4449.

Bailey, J., Douglas, H., Masino, L., de Carvalho, L. P. S., & Argyrou, A. (2021). Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B. Biochemistry, 60(47), 3621-3632.

Hassanzadeh, A., Hosseinzadeh, E., Rezapour, S., Vahedi, G., Haghnavaz, N., & Marofi, F. (2019). Quercetin promotes cell cycle arrest and apoptosis and attenuates the proliferation of human chronic myeloid leukemia cell line-K562 through interaction with HSPs (70 and 90), MAT2A and FOXM1. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 19(12), 1523-1534.

Simile, M. M., Peitta, G., Tomasi, M. L., Brozzetti, S., Feo, C. F., Porcu, A., ... & Pascale, R. M. (2019). MicroRNA-203 impacts on the growth, aggressiveness and prognosis of hepatocellular carcinoma by targeting MAT2A and MAT2B genes. Oncotarget, 10(29), 2835.

Wang, K., Fang, S., Liu, Q., Gao, J., Wang, X., Zhu, H., ... & Zhou, H. (2019). TGF-β1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM. EBioMedicine, 42, 458-469.

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For research use only. Not intended for any clinical use.

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