Mouse Anti-MATK Recombinant Antibody (9D7) (CBMAB-AO723LY)

Name: Mouse Anti-MATK Recombinant Antibody (9D7)
SKU: CBMAB-AO723LY
Rating: 5 (1 reviews)

See all MATK antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

9D7

Application

WB, FC

Immunogen

Purified recombinant fragment of human MATK expressed in E. coli.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.03% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Megakaryocyte-Associated Tyrosine Kinase

Introduction

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

4145

UniProt ID

P42679

Alternative Names

Megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK; CTK; HYL; MATK

Function

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.

Biological Process

Positive regulation of cell population proliferation Source: ProtInc
Protein phosphorylation Source: ProtInc

Cellular Location

Cytoplasm and Cytosol
Other locations
Membrane
Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-MATK Recombinant Antibody (9D7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-MATK Recombinant Antibody (CBT4533) (CAT#: V2LY-0625-LY2383)

Mouse Anti-MATK Recombinant Antibody (CBFYM-1760) (CAT#: CBMAB-M1928-FY)

Mouse Anti-MATK Recombinant Antibody (CBT853) (CAT#: V2LY-0625-LY3227)

Mouse Anti-MATK Recombinant Antibody (10C9) (CAT#: CBMAB-0716-CN)

Mouse Anti-MATK Recombinant Antibody (CBFYM-1759) (CAT#: CBMAB-M1927-FY)

Rabbit Anti-MATK Recombinant Antibody (D2I6U) (CAT#: CBMAB-C3926-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry