Rabbit Anti-MAU2 Recombinant Antibody (CBXS-1381) (CBMAB-S4239-CQ)

This product is a rabbit antibody that recognizes MAU2. The antibody CBXS-1381 can be used for immunoassay techniques such as: WB, IP, FC, IF.
See all MAU2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Mouse, Rat, Human

Clone

CBXS-1381

Antibody Isotype

IgG

Application

WB, IP, FC, IF

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

MAU2 Sister Chromatid Cohesion Factor

Introduction

MAU2 (MAU2 Sister Chromatid Cohesion Factor) is a Protein Coding gene. Diseases associated with MAU2 include Cornelia De Lange Syndrome and Warsaw Breakage Syndrome. Among its related pathways are Mitotic Telophase/Cytokinesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.

Entrez Gene ID

Human	23383
Mouse	74549
Rat	290668

UniProt ID

Human	Q9Y6X3
Mouse	Q9D2X5
Rat	D3Z8G8

Alternative Names

MAU2 Sister Chromatid Cohesion Factor; KIAA0892; Cohesin Loading Complex Subunit SCC4 Homolog; Sister Chromatid Cohesion 4; Mau-2; SCC4;

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566).

Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).

Biological Process

Cell division Source: UniProtKB-KW
Cohesin loading Source: UniProtKB
Maintenance of mitotic sister chromatid cohesion Source: UniProtKB

Cellular Location

Nucleus
nucleoplasm
Nucleus
Other locations
Chromosome
Note: Binds to chromatin from the end of mitosis until prophase.

References

Eot-Houllier, G., Magnaghi-Jaulin, L., Bourgine, G., Smagulova, F., Giet, R., Watrin, E., & Jaulin, C. (2023). The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading at mitotic exit. Journal of cell science, 136(11).

van Schie, J. J., de Lint, K., Molenaar, T. M., Moronta Gines, M., Balk, J. A., Rooimans, M. A., ... & de Lange, J. (2023). CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin. Nucleic Acids Research, 51(18), 9594-9609.

Zuilkoski, C. M., & Skibbens, R. V. (2022). Integrating sister chromatid cohesion establishment to DNA replication. Genes, 13(4), 625.

Henrikus, S. S., & Costa, A. (2021). Towards a Structural Mechanism for Sister Chromatid Cohesion Establishment at the Eukaryotic Replication Fork. Biology, 10(6), 466.

Parenti, I., Diab, F., Gil, S. R., Mulugeta, E., Casa, V., Berutti, R., ... & Wendt, K. S. (2020). MAU2 and NIPBL variants impair the heterodimerization of the cohesin loader subunits and cause Cornelia de Lange syndrome. Cell Reports, 31(7).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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