MAU2

MAU2 (MAU2 Sister Chromatid Cohesion Factor) is a Protein Coding gene. Diseases associated with MAU2 include Cornelia De Lange Syndrome and Warsaw Breakage Syndrome. Among its related pathways are Mitotic Telophase/Cytokinesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.

Full Name

MAU2 Sister Chromatid Cohesion Factor

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566).

Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).

Biological Process

Cell division Source: UniProtKB-KW
Cohesin loading Source: UniProtKB
Maintenance of mitotic sister chromatid cohesion Source: UniProtKB

Cellular Location

Nucleus
nucleoplasm
Nucleus
Other locations
Chromosome
Note: Binds to chromatin from the end of mitosis until prophase.