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Mouse Anti-MAZ Antibody (1D5) (CBMAB-0637-YC)

Provided herein are mouse monoclonal antibodies against Human MAZ. The antibody clone 1D5 can be used for immunoassay techniques, such as IP, WB and MA.
See all MAZ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D5
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAZ
Introduction
MAZ (MYC-associated zinc finger protein (purine-binding transcription factor)) is a protein that in humans is encoded by the MAZ gene. MAZ has been shown to interact with BPTF and deleted in Colorectal cancer.
Entrez Gene ID
UniProt ID
Alternative Names
Pur-1; ZF87; Zif87; ZNF801
Function
Transcriptional regulator, potentially with dual roles in transcription initiation and termination.

Isoform 1:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157).

Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157).

Isoform 2:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922).

Isoform 3:
Binds DNA and functions as a transcriptional activator.
Biological Process
Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase II transcription Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: UniProtKB
Cellular Location
Nucleus
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.

Zheng, C., Wu, H., Zhang, S., Tian, R., Long, H., Zhang, H., ... & Zhu, X. (2023). Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer. Frontiers in Bioscience-Landmark, 28(8), 162.

Zheng, C., Wu, H., Jin, S., Li, D., Tan, S., & Zhu, X. (2022). Roles of Myc‐associated zinc finger protein in malignant tumors. Asia‐Pacific Journal of Clinical Oncology, 18(6), 506-514.

Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C., Holland, M. L., ... & Vernimmen, D. (2021). Identification of the transcription factor MAZ as a regulator of erythropoiesis. Blood Advances, 5(15), 3002-3015.

Xiao, T., Li, X., & Felsenfeld, G. (2021). The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization. Proceedings of the National Academy of Sciences, 118(7), e2023127118.

Ren, L. X., Qi, J. C., Zhao, A. N., Shi, B., Zhang, H., Wang, D. D., & Yang, Z. (2021). Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway. Cancer cell international, 21(1), 1-13.

Wang, Y., Sun, L., Qiu, W., Qi, W., Qi, Y., Liu, Z., ... & Lv, J. (2020). Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment. Aging (Albany NY), 12(7), 6129.

Xiao, T., Li, X., & Felsenfeld, G. (2020). The Myc-Associated Zinc Finger Protein (MAZ) Works Both Independently and Together with CTCF to Control Cohesin Positioning and Genome Organization. Available at SSRN 3549502.

Ortabozkoyun-Kara, H., Huang, P. Y., Cho, H., Narendra, V., Leroy, G., Skok, J. A., ... & Reinberg, D. (2020). A CRISPR screen identifies Myc-associated zinc finger protein (MAZ) as an insulator functioning at CTCF boundaries in Hox clusters. BioRxiv, 2020-08.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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