Mouse Anti-MAZ Recombinant Antibody (3D2) (CBMAB-A5322-LY)

Name: Mouse Anti-MAZ Recombinant Antibody (3D2)
SKU: CBMAB-A5322-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3D2

Application

WB, ELISA

Immunogen

MAZ (NP_002374, 332 a.a. ~ 440 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

MAZ

Entrez Gene ID

4150

UniProt ID

P56270

Alternative Names

PUR1; Pur-1; SAF-1; SAF-2; ZF87; ZNF801; Zif87

Function

Transcriptional regulator, potentially with dual roles in transcription initiation and termination.

Isoform 1:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157).

Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157).

Isoform 2:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922).

Isoform 3:
Binds DNA and functions as a transcriptional activator.

Biological Process

Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase II transcription Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: UniProtKB

Cellular Location

Nucleus
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.

Zheng, C., Wu, H., Zhang, S., Tian, R., Long, H., Zhang, H., ... & Zhu, X. (2023). Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer. Frontiers in Bioscience-Landmark, 28(8), 162.

Zheng, C., Wu, H., Jin, S., Li, D., Tan, S., & Zhu, X. (2022). Roles of Myc‐associated zinc finger protein in malignant tumors. Asia‐Pacific Journal of Clinical Oncology, 18(6), 506-514.

Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C., Holland, M. L., ... & Vernimmen, D. (2021). Identification of the transcription factor MAZ as a regulator of erythropoiesis. Blood Advances, 5(15), 3002-3015.

Xiao, T., Li, X., & Felsenfeld, G. (2021). The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization. Proceedings of the National Academy of Sciences, 118(7), e2023127118.

Ren, L. X., Qi, J. C., Zhao, A. N., Shi, B., Zhang, H., Wang, D. D., & Yang, Z. (2021). Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway. Cancer cell international, 21(1), 1-13.

Wang, Y., Sun, L., Qiu, W., Qi, W., Qi, Y., Liu, Z., ... & Lv, J. (2020). Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment. Aging (Albany NY), 12(7), 6129.

Xiao, T., Li, X., & Felsenfeld, G. (2020). The Myc-Associated Zinc Finger Protein (MAZ) Works Both Independently and Together with CTCF to Control Cohesin Positioning and Genome Organization. Available at SSRN 3549502.

Ortabozkoyun-Kara, H., Huang, P. Y., Cho, H., Narendra, V., Leroy, G., Skok, J. A., ... & Reinberg, D. (2020). A CRISPR screen identifies Myc-associated zinc finger protein (MAZ) as an insulator functioning at CTCF boundaries in Hox clusters. BioRxiv, 2020-08.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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