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Mouse Anti-MBD5 Recombinant Antibody (CBFYM-0585) (CBMAB-M0716-FY)

This product is mouse antibody that recognizes MBD5. The antibody CBFYM-0585 can be used for immunoassay techniques such as: ELISA, WB.
See all MBD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0585
Antibody Isotype
IgG1, k
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Methyl-CpG Binding Domain Protein 5
Introduction
This gene encodes a member of the methyl-CpG-binding domain family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain, which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
Entrez Gene ID
55777
UniProt ID
Q9P267
Alternative Names
Methyl-CpG Binding Domain Protein 5; Methyl-CpG-Binding Protein MBD5; Methyl-CpG-Binding Domain Protein 5; KIAA1461; MRD1
Function
Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Biological Process
Glucose homeostasis Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of growth hormone receptor signaling pathway Source: UniProtKB
Regulation of behavior Source: UniProtKB
Regulation of multicellular organism growth Source: UniProtKB
Cellular Location
Isoform 1:
Nucleus
Other locations
Chromosome
Note: Associated with pericentric heterochromatin.
Isoform 2:
Nucleus
Note: Not associated with pericentric heterochromatin.
Involvement in disease
Mental retardation, autosomal dominant 1 (MRD1):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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