MBD5 Matched Antibody Pair (721) (APMAB-721LY)

Name: MBD5 Matched Antibody Pair (721)
SKU: APMAB-721LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-MBD5 polyclonal antibody, 100 ug

Detection Antibody

Anti-MBD5 Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]

Alternative Names

Methyl-CpG Binding Domain Protein 5; Methyl-CpG-Binding Protein MBD5; Methyl-CpG-Binding Domain Protein 5; KIAA1461; MRD1;

Entrez Gene ID

55777

UniProt ID

Q9P267

More Infomation

References

Coelho, F. S., Sangi, S., Moraes, J. L., da Silva Santos, W., Gamosa, E. A., Fernandes, K. V. S., & Grativol, C. (2022). Methyl-CpG binding proteins (MBD) family evolution and conservation in plants. Gene, 824, 146404.

Xiao, Y., Li, M., & Wang, J. (2022). The impacts of allopolyploidization on Methyl-CpG-Binding Domain (MBD) gene family in Brassica napus. BMC Plant Biology, 22(1), 103.

Ichino, L., Boone, B. A., Strauskulage, L., Harris, C. J., Kaur, G., Gladstone, M. A., ... & Jacobsen, S. E. (2021). MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO. Science, 372(6549), 1434-1439.

Chen, Y., Li, Y., Ren, H., Zhou, J., Wang, L., Yang, Y., ... & Wang, X. (2021). Genome-wide identification and expression profiling reveal the diverse role of Methyl-CpG-binding domain proteins in tea plant Camellia sinensis. Beverage Plant Research, 1(1), 1-12.

Song, X., Zhang, Y., Zhong, Q., Zhan, K., Bi, J., Tang, J., ... & Li, B. (2020). Identification and functional characterization of methyl-CpG binding domain protein from Tribolium castaneum. Genomics, 112(3), 2223-2232.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-MBD5 Recombinant Antibody (CBFYM-0585)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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Second antibody and isotype control

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