Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0589) (CBMAB-M0720-FY)

Name: Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0589)
SKU: CBMAB-M0720-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0589

Application

ELISA, RIA

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mannose Binding Lectin 2

Introduction

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.

Entrez Gene ID

4153

UniProt ID

P11226

Alternative Names

Mannose Binding Lectin 2; Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect); Collectin-1; COLEC1; MBP-C; MBP1; MBL; Mannose-Binding Lectin 2, Soluble (Opsonic Defect); Mannose-Binding Lectin (Protein C) 2, Soluble

Function

Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).

Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).

Biological Process

Acute-phase response Source: BHF-UCL
Cell surface pattern recognition receptor signaling pathway Source: ComplexPortal
Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to bacterium Source: BHF-UCL
Defense response to Gram-positive bacterium Source: MGI
Innate immune response Source: BHF-UCL
Killing by host of symbiont cells Source: Ensembl
Negative regulation of viral process Source: BHF-UCL
Opsonization Source: BHF-UCL
Positive regulation of opsonization Source: ComplexPortal
Proteolysis Source: ComplexPortal
Response to oxidative stress Source: UniProtKB

Cellular Location

Secreted

Liao, H., Yang, J., Xu, Y., Xie, J., Li, K., Chen, K., ... & Pan, M. (2023). Mannose-Binding Lectin 2 as a Potential Therapeutic Target for Hepatocellular Carcinoma: Multi-Omics Analysis and Experimental Validation. Cancers, 15(19), 4900.

Uysalol, M., Gumus, S., Yildiz, R., Pasli Uysalol, E., Pehlivan, S., Pehlivan, M., & Serin, I. (2022). Importance of mannose-binding lectin2 polymorphism (rs1800450) in infections in children. Biomarkers, 27(1), 44-49.

Doulami, C., Kishore, U., Sim, R. B., & Schwaeble, W. (2021). Mannose-binding lectin in human health and disease. The Collectin Protein Family and Its Multiple Biological Activities, 17-47.

Kalia, N., Singh, J., & Kaur, M. (2021). The ambiguous role of mannose-binding lectin (MBL) in human immunity. Open Medicine, 16(1), 299-310.

Bąk-Romaniszyn, L., Świerzko, A. S., Sokołowska, A., Durko, Ł., Mierzwa, G., Szala-Poździej, A., ... & Cedzyński, M. (2020). Mannose-binding lectin (MBL) in adult patients with inflammatory bowel disease. Immunobiology, 225(1), 151859.

Polesello, V., Segat, L., Biasotto, M., Ottaviani, G., Gobbo, M., Di Lenarda, R., ... & Zupin, L. (2019). Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus. Genetics and Molecular Biology, 42, 9-14.

Tong, X., Wan, Q., Li, Z., Liu, S., Huang, J., Wu, M., & Fan, H. (2019). Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review. Microbial pathogenesis, 132, 374-380.

Ulrich-Merzenich, G., Hausen, A., Zeitler, H., Goldmann, G., Oldenburg, J., & Pavlova, A. (2019). The role of variant alleles of the mannose-binding lectin in the inhibitor development in severe hemophilia A. Thrombosis Research, 179, 140-146.

Videbaek, K., Buchvald, F., Holgersen, M. G., Henriksen, A., Eriksson, F., Garred, P., & Nielsen, K. G. (2019). The impact of mannose‐binding lectin polymorphisms on lung function in primary ciliary dyskinesia. Pediatric Pulmonology, 54(8), 1182-1189.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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