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MBL2

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]
Full Name
Mannose Binding Lectin 2
Function
Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).

Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).
Biological Process
Acute-phase response Source: BHF-UCL
Cell surface pattern recognition receptor signaling pathway Source: ComplexPortal
Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to bacterium Source: BHF-UCL
Defense response to Gram-positive bacterium Source: MGI
Innate immune response Source: BHF-UCL
Killing by host of symbiont cells Source: Ensembl
Negative regulation of viral process Source: BHF-UCL
Opsonization Source: BHF-UCL
Positive regulation of opsonization Source: ComplexPortal
Proteolysis Source: ComplexPortal
Response to oxidative stress Source: UniProtKB
Cellular Location
Secreted

Anti-MBL2 antibodies

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Mouse Anti-MBL2 Recombinant Antibody (CBFYA-0097) (CBMAB-X0140-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0097
Application*: F, C, FN, IA

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1829) (CBMAB-M1997-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat
Clone: CBFYM-1829
Application*: C, P

Rabbit Anti-MBL2 Recombinant Antibody (CBFYM-1828) (CBMAB-M1996-FY)

Datasheet SDS
Target: MBL2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBFYM-1828
Application*: WB, F

Rat Anti-MBL2 Recombinant Antibody (CBFYM-1827) (CBMAB-M1995-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-1827
Application*: C, E, IF, WB

Rat Anti-MBL2 (AA 19-244) Recombinant Antibody (CBFYM-1825) (CBMAB-M1993-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYM-1825
Application*: WB

Rabbit Anti-MBL2 Recombinant Antibody (CBFYM-1824) (CBMAB-M1992-FY)

Datasheet SDS
Target: MBL2
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBFYM-1824
Application*: IF, IH, WB

Mouse Anti-MBL2 (AA 67-74) Recombinant Antibody (CBFYM-1823) (CBMAB-M1991-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1823
Application*: C, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1822) (CBMAB-M1990-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1822
Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1820) (CBMAB-M1988-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Horse, Human, Pig
Clone: CBFYM-1820
Application*: E, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1819) (CBMAB-M1987-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Goat, Human, Mouse, Rabbit, Rat, Sheep
Clone: CBFYM-1819
Application*: E, C, P, WB

Mouse Anti-MBL2 (AA 130-136 ) Recombinant Antibody (CBFYM-1818) (CBMAB-M1986-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Goat, Human, Mouse, Rabbit, Rat, Sheep
Clone: CBFYM-1818
Application*: E, WB, IH

Mouse Anti-MBL2 (AA 129-138) Recombinant Antibody (CBFYM-1817) (CBMAB-M1985-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human, Rat
Clone: CBFYM-1817
Application*: C, E

Mouse Anti-MBL2 (AA 1-118) Recombinant Antibody (CBFYM-1816) (CBMAB-M1984-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Guinea pig, Rabbit, Sheep, Human
Clone: CBFYM-1816
Application*: R, E

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1815) (CBMAB-M1983-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Guinea pig, Human, Sheep, Rabbit, Rat
Clone: CBFYM-1815
Application*: E, C

Mouse Anti-MBL2 (AA 45-91 ) Recombinant Antibody (CBFYM-1814) (CBMAB-M1982-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Guinea pig, Human, Rabbit, Sheep
Clone: CBFYM-1814
Application*: E, P, R

Rat Anti-MBL2 (AA 82-87) Recombinant Antibody (CBFYM-1813) (CBMAB-M1981-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Cattle, Chicken, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Sheep
Clone: CBFYM-1813
Application*: E, P, R, WB

Mouse Anti-MBL2 (AA 129-138) Recombinant Antibody (CBFYM-1812) (CBMAB-M1980-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBFYM-1812
Application*: E, C, WB

Rat Anti-MBL2 Recombinant Antibody (CBFYM-1811) (CBMAB-M1979-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG
Specificity: Cattle
Clone: CBFYM-1811
Application*: E, IH, R

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-1809) (CBMAB-M1977-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken
Clone: CBFYM-1809
Application*: E, IH, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0594) (CBMAB-M0726-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0594
Application*: IP, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0593) (CBMAB-M0725-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0593
Application*: IP

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0592) (CBMAB-M0724-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0592
Application*: E, IH, WB

Mouse Anti-MBL2 (AA 147-158) Recombinant Antibody (CBFYM-0591) (CBMAB-M0723-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0591
Application*: IH, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0590) (CBMAB-M0722-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0590
Application*: E, IF, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0589) (CBMAB-M0720-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0589
Application*: E, R

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0588) (CBMAB-M0719-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0588
Application*: E, IP, WB

Rat Anti-MBL2 (AA 36-50) Recombinant Antibody (CBFYM-0587) (CBMAB-M0718-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: CBFYM-0587
Application*: E, C, P

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0349) (CBMAB-M0424-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0349
Application*: E, WB, IH

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0263) (CBMAB-M0328-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0263
Application*: F, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0262) (CBMAB-M0327-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Specificity: Human
Clone: CBFYM-0262
Application*: E, F, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0233) (CBMAB-M0278-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0233
Application*: F, IH, WB

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0135) (CBMAB-M0155-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0135
Application*: F, E

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0132) (CBMAB-M0152-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0132
Application*: SE

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0121) (CBMAB-M0139-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0121
Application*: WB, F, E, IF, P

Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0023) (CBMAB-M0027-FY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0023
Application*: WB, E

Mouse Anti-MBL2 Recombinant Antibody (11F11) (CBMAB-AO731LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 11F11
Application*: ELISA, WB

Mouse Anti-MBL2 Recombinant Antibody (15C5) (CBMAB-AO730LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Hamster, Pig
Clone: 15C5
Application*: ELISA, WB

Mouse Anti-MBL2 Recombinant Antibody (6B11) (CBMAB-AO729LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: 6B11
Application*: ELISA, WB, IHC

Mouse Anti-MBL2 Recombinant Antibody (1E2) (CBMAB-AO728LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E2
Application*: ELISA, WB

Mouse Anti-MBL2 Recombinant Antibody (11C9) (CBMAB-AO727LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11C9
Application*: ELISA, WB

Mouse Anti-MBL2 Recombinant Antibody (3B6) (CBMAB-AO726LY)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B6
Application*: ELISA, WB, IHC

Recombinant Rat Anti-MBL2 Antibody (CBHb025) (CBMAB-Hb743-LY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb025
Application*: Immuno assays, WB

Rat Anti-MBL2 Recombinant Antibody (14D12) (CBMAB-X0026-FY)

Datasheet SDS
Target: MBL2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 14D12
Application*: C, IA, IF, WB

Mouse Anti-MBL2 Recombinant Antibody (J175-7D4) (CBMAB-P0498-YC)

Datasheet SDS
Target: MBL2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: J175-7D4
Application*: IS, IP, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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