Mouse Recombinant MBL2 protein, His Tag (V2LY-0526-LY8641)

Name: Mouse Recombinant MBL2 protein, His Tag
SKU: V2LY-0526-LY8641
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant MBL2 protein, His Tag consist of Amino Acid: 19-244 and predicts a molecular mass of 26.3 kDa.

Molecule Mass

26.3 kDa

Sequence

Amino Acid: 19-244

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Mannose Binding Lectin 2

Function

Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).

Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).

Biological Process

Acute-phase response Source: BHF-UCL
Cell surface pattern recognition receptor signaling pathway Source: ComplexPortal
Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to bacterium Source: BHF-UCL
Defense response to Gram-positive bacterium Source: MGI
Innate immune response Source: BHF-UCL
Killing by host of symbiont cells Source: Ensembl
Negative regulation of viral process Source: BHF-UCL
Opsonization Source: BHF-UCL
Positive regulation of opsonization Source: ComplexPortal
Proteolysis Source: ComplexPortal
Response to oxidative stress Source: UniProtKB

Cellular Location

Secreted

Liao, H., Yang, J., Xu, Y., Xie, J., Li, K., Chen, K., ... & Pan, M. (2023). Mannose-Binding Lectin 2 as a Potential Therapeutic Target for Hepatocellular Carcinoma: Multi-Omics Analysis and Experimental Validation. Cancers, 15(19), 4900.

Uysalol, M., Gumus, S., Yildiz, R., Pasli Uysalol, E., Pehlivan, S., Pehlivan, M., & Serin, I. (2022). Importance of mannose-binding lectin2 polymorphism (rs1800450) in infections in children. Biomarkers, 27(1), 44-49.

Doulami, C., Kishore, U., Sim, R. B., & Schwaeble, W. (2021). Mannose-binding lectin in human health and disease. The Collectin Protein Family and Its Multiple Biological Activities, 17-47.

Kalia, N., Singh, J., & Kaur, M. (2021). The ambiguous role of mannose-binding lectin (MBL) in human immunity. Open Medicine, 16(1), 299-310.

Bąk-Romaniszyn, L., Świerzko, A. S., Sokołowska, A., Durko, Ł., Mierzwa, G., Szala-Poździej, A., ... & Cedzyński, M. (2020). Mannose-binding lectin (MBL) in adult patients with inflammatory bowel disease. Immunobiology, 225(1), 151859.

Polesello, V., Segat, L., Biasotto, M., Ottaviani, G., Gobbo, M., Di Lenarda, R., ... & Zupin, L. (2019). Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus. Genetics and Molecular Biology, 42, 9-14.

Tong, X., Wan, Q., Li, Z., Liu, S., Huang, J., Wu, M., & Fan, H. (2019). Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review. Microbial pathogenesis, 132, 374-380.

Ulrich-Merzenich, G., Hausen, A., Zeitler, H., Goldmann, G., Oldenburg, J., & Pavlova, A. (2019). The role of variant alleles of the mannose-binding lectin in the inhibitor development in severe hemophilia A. Thrombosis Research, 179, 140-146.

Videbaek, K., Buchvald, F., Holgersen, M. G., Henriksen, A., Eriksson, F., Garred, P., & Nielsen, K. G. (2019). The impact of mannose‐binding lectin polymorphisms on lung function in primary ciliary dyskinesia. Pediatric Pulmonology, 54(8), 1182-1189.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MBL2 protein (CAT#: V2LY-0526-LY5425)

Mouse Recombinant MBL2 protein, Fc Tag (CAT#: V2LY-0526-LY8642)

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Isotype control

For research use only. Not intended for any clinical use.

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