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Mouse Anti-MBL2 Recombinant Antibody (CBFYM-0121) (CBMAB-M0139-FY)

This product is mouse antibody that recognizes MBL2. The antibody CBFYM-0121 can be used for immunoassay techniques such as: WB, FC, ELISA, IF, IHC-P.
See all MBL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0121
Antibody Isotype
IgG1
Application
WB, FC, ELISA, IF, IHC-P

Basic Information

Immunogen
Recombinant fragment of human Myelin Basic Protein expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mannose Binding Lectin 2
Introduction
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
Entrez Gene ID
4153
UniProt ID
P11226
Alternative Names
Mannose Binding Lectin 2; Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect); Collectin-1; COLEC1; MBP-C; MBP1; MBL; Mannose-Binding Lectin 2, Soluble (Opsonic Defect); Mannose-Binding Lectin (Protein C) 2, Soluble
Function
Calcium-dependent lectin involved in innate immune defense (PubMed:35102342).

Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).
Biological Process
Acute-phase response Source: BHF-UCL
Cell surface pattern recognition receptor signaling pathway Source: ComplexPortal
Complement activation, classical pathway Source: UniProtKB-KW
Complement activation, lectin pathway Source: MGI
Defense response to bacterium Source: BHF-UCL
Defense response to Gram-positive bacterium Source: MGI
Innate immune response Source: BHF-UCL
Killing by host of symbiont cells Source: Ensembl
Negative regulation of viral process Source: BHF-UCL
Opsonization Source: BHF-UCL
Positive regulation of opsonization Source: ComplexPortal
Proteolysis Source: ComplexPortal
Response to oxidative stress Source: UniProtKB
Cellular Location
Secreted

Liao, H., Yang, J., Xu, Y., Xie, J., Li, K., Chen, K., ... & Pan, M. (2023). Mannose-Binding Lectin 2 as a Potential Therapeutic Target for Hepatocellular Carcinoma: Multi-Omics Analysis and Experimental Validation. Cancers, 15(19), 4900.

Uysalol, M., Gumus, S., Yildiz, R., Pasli Uysalol, E., Pehlivan, S., Pehlivan, M., & Serin, I. (2022). Importance of mannose-binding lectin2 polymorphism (rs1800450) in infections in children. Biomarkers, 27(1), 44-49.

Doulami, C., Kishore, U., Sim, R. B., & Schwaeble, W. (2021). Mannose-binding lectin in human health and disease. The Collectin Protein Family and Its Multiple Biological Activities, 17-47.

Kalia, N., Singh, J., & Kaur, M. (2021). The ambiguous role of mannose-binding lectin (MBL) in human immunity. Open Medicine, 16(1), 299-310.

Bąk-Romaniszyn, L., Świerzko, A. S., Sokołowska, A., Durko, Ł., Mierzwa, G., Szala-Poździej, A., ... & Cedzyński, M. (2020). Mannose-binding lectin (MBL) in adult patients with inflammatory bowel disease. Immunobiology, 225(1), 151859.

Polesello, V., Segat, L., Biasotto, M., Ottaviani, G., Gobbo, M., Di Lenarda, R., ... & Zupin, L. (2019). Mannose-Binding Lectin 2 (MBL2) combined genotypes deficiency is associated with susceptibility for Oral Lichen Planus. Genetics and Molecular Biology, 42, 9-14.

Tong, X., Wan, Q., Li, Z., Liu, S., Huang, J., Wu, M., & Fan, H. (2019). Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review. Microbial pathogenesis, 132, 374-380.

Ulrich-Merzenich, G., Hausen, A., Zeitler, H., Goldmann, G., Oldenburg, J., & Pavlova, A. (2019). The role of variant alleles of the mannose-binding lectin in the inhibitor development in severe hemophilia A. Thrombosis Research, 179, 140-146.

Videbaek, K., Buchvald, F., Holgersen, M. G., Henriksen, A., Eriksson, F., Garred, P., & Nielsen, K. G. (2019). The impact of mannose‐binding lectin polymorphisms on lung function in primary ciliary dyskinesia. Pediatric Pulmonology, 54(8), 1182-1189.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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