Sign in or Register   Sign in or Register
  |  

Recombinant Mouse Anti-MC1R Antibody (CBAb161) (CBMAB-Ab161-LY)

The product is antibody recognizes MC1R. The antibody CBAb161 immunoassay techniques such as: WB 1:500-1:1000.
See all MC1R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBAb161
Antibody Isotype
IgM
Application
WB, IP

Basic Information

Immunogen
Raised against a synthetic peptide corresponding to amino acids 205-232 in a central region of MC1-R of human origin
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Melanocortin 1 Receptor
Introduction
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Entrez Gene ID
4157
UniProt ID
Q01726
Alternative Names
MC1R; CMM5; MSH-R; SHEP2; melanocortin 1 receptor
Function
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265).

The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927).

Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Intracellular signal transduction Source: BHF-UCL
Melanin biosynthetic process Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of tumor necrosis factor production Source: BHF-UCL
Pigmentation Source: BHF-UCL
Positive regulation of feeding behavior Source: Ensembl
Positive regulation of protein kinase A signaling Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of protein kinase C signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of metabolic process Source: GO_Central
Sensory perception of pain Source: Ensembl
UV-damage excision repair Source: BHF-UCL
UV protection Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Melanoma, cutaneous malignant 5 (CMM5):
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Topology
Extracellular: 1-37
Helical: 38-63
Cytoplasmic: 64-72
Helical: 73-93
Extracellular: 94-118
Helical: 119-140
Cytoplasmic: 141-163
Helical: 164-183
Extracellular: 184-191
Helical: 192-211
Cytoplasmic: 212-240
Helical: 241-266
Extracellular: 267-279
Helical: 280-300
Cytoplasmic: 301-317

Mun, Y., Kim, W., & Shin, D. (2023). Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. International Journal of Molecular Sciences, 24(15), 12152.

Guida, S., Guida, G., & Goding, C. R. (2022). MC1R functions, expression, and implications for targeted therapy. Journal of Investigative Dermatology, 142(2), 293-302.

Ji, R. L., & Tao, Y. X. (2022). Melanocortin-1 receptor mutations and pigmentation: Insights from large animals. Progress in molecular biology and translational science, 189(1), 179-213.

Suzuki, T., Kawano, Y., Matsumoto, A., Kondo, M., Funayama, K., Tanemura, S., ... & Yamamoto, Y. (2022). Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist. Skin Health and Disease, 2(1), e78.

Herraiz, C., Martínez‐Vicente, I., & Maresca, V. (2021). The α‐melanocyte‐stimulating hormone/melanocortin‐1 receptor interaction: A driver of pleiotropic effects beyond pigmentation. Pigment cell & melanoma research, 34(4), 748-761.

Guida, S., Ciardo, S., De Pace, B., De Carvalho, N., Farnetani, F., Pezzini, C., ... & Pellacani, G. (2021). Atrophic and hypertrophic skin photoaging and melanocortin-1 receptor (MC1R): the missing link. Journal of the American Academy of Dermatology, 84(1), 187-190.

Bautista, R. M., Carter, K. M., Jarrett, S. G., Napier, D., Wakamatsu, K., Ito, S., & D'Orazio, J. A. (2020). Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skin. Pigment cell & melanoma research, 33(1), 30-40.

Ji, L. Q., Rao, Y. Z., Zhang, Y., Chen, R., & Tao, Y. X. (2020). Regulation of melanocortin-1 receptor pharmacology by melanocortin receptor accessory protein 2 in orange-spotted grouper (Epinephelus coioides). General and Comparative Endocrinology, 285, 113291.

Li, M., Liu, D., Lee, D., Kapoor, S., Gibson-Corley, K. N., Quinn, T. P., ... & Schultz, M. K. (2019). Enhancing the efficacy of melanocortin 1 receptor-targeted radiotherapy by pharmacologically upregulating the receptor in metastatic melanoma. Molecular pharmaceutics, 16(9), 3904-3915.

Abdullah, M. M., Yousif, A. N., Amen, Q. A., & Shaker, A. S. (2019, November). Detection of Melanocortin 1 Receptor (MC1R) polymorphism and its relation to plumage colors in local turkey. In IOP Conference Series: Earth and Environmental Science (Vol. 388, No. 1, p. 012033). IOP Publishing.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Recombinant Mouse Anti-MC1R Antibody (CBAb161)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare