Mouse Mc1r ELISA Kit (V2LY-0626-LY2621)

Go to compare Compare Online Inquiry
Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0096 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
35.2 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Melanocortin 1 Receptor
Function
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670, PubMed:8463333, PubMed:1516719, PubMed:11442765, PubMed:11707265).

The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670, PubMed:11707265, PubMed:16463023, PubMed:19737927).

Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Intracellular signal transduction Source: BHF-UCL
Melanin biosynthetic process Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of tumor necrosis factor production Source: BHF-UCL
Pigmentation Source: BHF-UCL
Positive regulation of feeding behavior Source: Ensembl
Positive regulation of protein kinase A signaling Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of protein kinase C signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of metabolic process Source: GO_Central
Sensory perception of pain Source: Ensembl
UV-damage excision repair Source: BHF-UCL
UV protection Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Melanoma, cutaneous malignant 5 (CMM5):
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Topology
Extracellular: 1-37
Helical: 38-63
Cytoplasmic: 64-72
Helical: 73-93
Extracellular: 94-118
Helical: 119-140
Cytoplasmic: 141-163
Helical: 164-183
Extracellular: 184-191
Helical: 192-211
Cytoplasmic: 212-240
Helical: 241-266
Extracellular: 267-279
Helical: 280-300
Cytoplasmic: 301-317

Mun, Y., Kim, W., & Shin, D. (2023). Melanocortin 1 Receptor (MC1R): Pharmacological and Therapeutic Aspects. International Journal of Molecular Sciences, 24(15), 12152.

Guida, S., Guida, G., & Goding, C. R. (2022). MC1R functions, expression, and implications for targeted therapy. Journal of Investigative Dermatology, 142(2), 293-302.

Ji, R. L., & Tao, Y. X. (2022). Melanocortin-1 receptor mutations and pigmentation: Insights from large animals. Progress in molecular biology and translational science, 189(1), 179-213.

Suzuki, T., Kawano, Y., Matsumoto, A., Kondo, M., Funayama, K., Tanemura, S., ... & Yamamoto, Y. (2022). Melanogenic effect of dersimelagon (MT‐7117), a novel oral melanocortin 1 receptor agonist. Skin Health and Disease, 2(1), e78.

Herraiz, C., Martínez‐Vicente, I., & Maresca, V. (2021). The α‐melanocyte‐stimulating hormone/melanocortin‐1 receptor interaction: A driver of pleiotropic effects beyond pigmentation. Pigment cell & melanoma research, 34(4), 748-761.

Guida, S., Ciardo, S., De Pace, B., De Carvalho, N., Farnetani, F., Pezzini, C., ... & Pellacani, G. (2021). Atrophic and hypertrophic skin photoaging and melanocortin-1 receptor (MC1R): the missing link. Journal of the American Academy of Dermatology, 84(1), 187-190.

Bautista, R. M., Carter, K. M., Jarrett, S. G., Napier, D., Wakamatsu, K., Ito, S., & D'Orazio, J. A. (2020). Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor‐intact or heterozygous skin. Pigment cell & melanoma research, 33(1), 30-40.

Ji, L. Q., Rao, Y. Z., Zhang, Y., Chen, R., & Tao, Y. X. (2020). Regulation of melanocortin-1 receptor pharmacology by melanocortin receptor accessory protein 2 in orange-spotted grouper (Epinephelus coioides). General and Comparative Endocrinology, 285, 113291.

Li, M., Liu, D., Lee, D., Kapoor, S., Gibson-Corley, K. N., Quinn, T. P., ... & Schultz, M. K. (2019). Enhancing the efficacy of melanocortin 1 receptor-targeted radiotherapy by pharmacologically upregulating the receptor in metastatic melanoma. Molecular pharmaceutics, 16(9), 3904-3915.

Abdullah, M. M., Yousif, A. N., Amen, Q. A., & Shaker, A. S. (2019, November). Detection of Melanocortin 1 Receptor (MC1R) polymorphism and its relation to plumage colors in local turkey. In IOP Conference Series: Earth and Environmental Science (Vol. 388, No. 1, p. 012033). IOP Publishing.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Mc1r ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.