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Mouse Anti-MCAM Recombinant Antibody (CBYY-C2652) (CBMAB-C4093-YY)

This product is mouse antibody that recognizes MCAM. The antibody CBYY-C2652 can be used for immunoassay techniques such as: FC, WB
See all MCAM antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYY-C2652
Antibody Isotype
IgG2a
Application
FC, WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant rat MCAM/CD146 Arg19-Lys560
Specificity
Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.5 mg/mL
Preservative
PBS, 5% trehalose
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Melanoma Cell Adhesion Molecule
Entrez Gene ID
UniProt ID
Alternative Names
Mucin 16, Cell Surface Associated; Ovarian Cancer-Related Tumor Marker CA125; Ovarian Carcinoma Antigen CA125; CA125; CA125 Ovarian Cancer Antigen; Mucin-16; CA-125; MUC-16;
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: MGI
Cell adhesion Source: ProtInc
Glomerular filtration Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Vascular wound healing Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 24-559
Helical: 560-583
Cytoplasmic: 584-646
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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