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Rat Anti-MCAM Recombinant Antibody (ME-9F1) (CBMAB-C1792-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
ME-9F1
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
MCAM (Melanoma Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with MCAM include Melanoma and Melanoma Metastasis. Among its related pathways are Adhesion. An important paralog of this gene is BCAM.
Entrez Gene ID
84004
UniProt ID
Q8R2Y2
Alternative Names
Melanoma Cell Adhesion Molecule; S-Endo 1 Endothelial-Associated Antigen; Melanoma-Associated Antigen MUC18; Cell Surface Glycoprotein P1H12; Melanoma-Associated Antigen A32; Gicerin;
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: MGI
Cell adhesion Source: ProtInc
Glomerular filtration Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Vascular wound healing Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 24-559
Helical: 560-583
Cytoplasmic: 584-646
More Infomation

Pang, Y., Maxwell, E., Sindrewicz-Goral, P., Shapanis, A., Li, S., Morgan, M., & Yu, L. G. (2022). Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression. Biomolecules, 12(10), 1451.

Ikeguchi, R., Shimizu, Y., Kondo, A., Kanda, N., So, H., Kojima, H., & Kitagawa, K. (2021). Melanoma cell adhesion molecule expressing helper T cells in CNS inflammatory demyelinating diseases. Neurology-Neuroimmunology Neuroinflammation, 8(6).

Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., & Yan, X. (2020). CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal transduction and targeted therapy, 5(1), 148.

Petersen, E. R., Ammitzbøll, C., Søndergaard, H. B., Oturai, A. B., Sørensen, P. S., Nilsson, A. C., ... & Sellebjerg, F. (2019). Expression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis. Journal of Neuroimmunology, 337, 577085.

Chen, Y., Sumardika, I. W., Tomonobu, N., Ruma, I. M. W., Kinoshita, R., Kondo, E., ... & Sakaguchi, M. (2019). Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion. Cancer Letters, 452, 178-190.

Čorić, M. (2019). Development and characterisation of monoclonal antibodies to tumour endothelial marker ‘melanoma cell adhesion molecule’(MCAM) and approaches to targeting MCAM on tumour vessels (Doctoral dissertation, University of Birmingham).

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For research use only. Not intended for any clinical use.

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