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Mouse Anti-MCPH1 Recombinant Antibody (11C3) (CBMAB-0724-CN)

This product is a mouse antibody that recognizes MCPH1 of human. The antibody 11C3 can be used for immunoassay techniques such as: ELISA, MA.
See all MCPH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11C3
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein of MCPH1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MCPH1
Introduction
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. The protein is implicated in chromosome condensation and DNA damage induced cellular responses. It may also play a role in neurogenesis and regulation of the size of the cerebral cortex.
Entrez Gene ID
79648
UniProt ID
Q8NEM0
Alternative Names
MCT; BRIT1
Function
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
Biological Process
Bone development Source: Ensembl
Cerebral cortex development Source: Ensembl
Establishment of mitotic spindle orientation Source: Ensembl
Mitotic cell cycle Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Neuronal stem cell population maintenance Source: Ensembl
Protein localization to centrosome Source: Ensembl
Regulation of centrosome cycle Source: Ensembl
Regulation of chromosome condensation Source: Ensembl
Regulation of inflammatory response Source: Ensembl
Regulation of kinase activity Source: Ensembl
Cellular Location
Centrosome
Involvement in disease
Microcephaly 1, primary, autosomal recessive (MCPH1):
A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Some MCHP1 patients also present growth retardation, short stature, and misregulated chromosome condensation as indicated by a high number of prophase-like cells detected in routine cytogenetic preparations and poor-quality metaphase G-banding.

Alsolami, M., Aboalola, D., Malibari, D., Alghamdi, T., Alshekhi, W., Jad, H., ... & Alsiary, R. A. (2023). The emerging role of MCPH1/BRIT1 in carcinogenesis. Frontiers in Oncology, 13, 230.

Wang, Y., Zong, W., Sun, W., Chen, C., Wang, Z. Q., & Li, T. (2022). The central domain of MCPH1 controls development of the cerebral cortex and gonads in mice. Cells, 11(17), 2715.

Caraffi, S. G., Pollazzon, M., Farooq, M., Fatima, A., Larsen, L. A., Zuntini, R., ... & Garavelli, L. (2022). MCPH1: A Novel Case Report and a Review of the Literature. Genes, 13(4), 634.

Kristofova, M., Ori, A., & Wang, Z. Q. (2022). Multifaceted microcephaly-related gene MCPH1. Cells, 11(2), 275.

Khan, N. M., Masoud, M. S., Baig, S. M., Qasim, M., & Chang, J. (2022). Identification of Pathogenic Mutations in Primary Microcephaly-(MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families. BioMed Research International, 2022.

Houlard, M., Cutts, E. E., Shamim, M. S., Godwin, J., Weisz, D., Aiden, A. P., ... & Nasmyth, K. (2021). MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface. Elife, 10, e73348.

Liu, X., Schneble-Löhnert, N., Kristofova, M., Qing, X., Labisch, J., Hofmann, S., ... & Wang, Z. Q. (2021). The N-terminal BRCT domain determines MCPH1 function in brain development and fertility. Cell Death & Disease, 12(2), 143.

Kristofova, M., & Wang, Z. Q. (2021). MCPH1, beyond its role deciding the brain size. Aging (Albany NY), 13(20), 23437.

Journiac, N., Gilabert-Juan, J., Cipriani, S., Benit, P., Liu, X., Jacquier, S., ... & Nardelli, J. (2020). Cell metabolic alterations due to Mcph1 mutation in microcephaly. Cell Reports, 31(2).

Shi, L., Luo, X., Jiang, J., Chen, Y., Liu, C., Hu, T., ... & Su, B. (2019). Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review, 6(3), 480-493.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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