Rabbit Anti-ME2 Recombinant Antibody (CBFYM-1975) (CBMAB-M2150-FY)

Name: Rabbit Anti-ME2 Recombinant Antibody (CBFYM-1975)
SKU: CBMAB-M2150-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYM-1975

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Gly450 of human malic enzyme (mitochondrial)

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Malic Enzyme 2

Introduction

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

Entrez Gene ID

Human	4200
Monkey	711129

UniProt ID

Human	P23368
Monkey	F6RIZ9

Alternative Names

Malic Enzyme 2; Malate Dehydrogenase (Oxaloacetate-Decarboxylating); Malic Enzyme 2, NAD(+)-Dependent, Mitochondrial; NAD-Dependent Malic Enzyme, Mitochondrial; NAD-ME; Pyruvic-Malic Carboxylase; EC 1.1.1.38; EC 1.1.1; ODS1

Function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate.

Biological Process

Malate metabolic process Source: GO_Central
Pyruvate metabolic process Source: GO_Central
Regulation of NADP metabolic process Source: CACAO

Cellular Location

Mitochondrion matrix

Chen, K. C., Hsiao, I. H., Huang, Y. N., Chou, Y. T., Lin, Y. C., Hsieh, J. Y., ... & Hung, H. C. (2023). Targeting human mitochondrial NAD (P)+-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia. Cellular Oncology, 1-16.

Zhang, Z., & Du, W. (2022). Malic enzyme 2 as a therapeutic target for cancer: comments on ‘Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate’. Journal of Molecular Cell Biology, 14(4), mjac024.

Zhao, M., Yao, P., Mao, Y., Wu, J., Wang, W., Geng, C., ... & Jiang, P. (2022). Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. Nature Metabolism, 4(2), 225-238.

Wang, Y. P., Sharda, A., Xu, S. N., Van Gastel, N., Man, C. H., Choi, U., ... & Scadden, D. T. (2021). Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. Cell Metabolism, 33(5), 1027-1041.

Zhang, S., Cheng, Z. M., Yu, J. L., Lu, K., Xu, S. J., Lu, Y., ... & Zhou, S. (2021). Malic enzyme 2 promotes the progression of hepatocellular carcinoma via increasing triglyceride production. Cancer Medicine, 10(19), 6795-6806.

You, D., Du, D., Zhao, X., Li, X., Ying, M., & Hu, X. (2021). Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia. Chinese Journal of Cancer Research, 33(3), 308.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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