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Mouse Anti-MEF2B Antibody (2A11) (CBMAB-0659-YC)

Provided herein are mouse monoclonal antibodies against Human MEF2B. The antibody clone 2A11 can be used for immunoassay techniques, such as IP, WB and MA.
See all MEF2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A11
Antibody Isotype
IgG2b
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MEF2B
Introduction
MEF2B (myocyte enhancer factor 2B) is a member of the MADS/MEF2 family of DNA binding proteins. MEF2B is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene.
Entrez Gene ID
100271849
UniProt ID
Q02080
Alternative Names
RSRFR2
Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Biological Process
Cell differentiation Source: GO_Central
Muscle organ development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Bayraktar, M., Durmuş, M., & Al-Shuhaib, M. B. S. (2023). Identification of two novel SNPs in the myocyte enhancer factor 2B (MEF2B) gene and its association with growth traits in two breeds of Turkish sheep. Small Ruminant Research, 218, 106867.

Torabi, A., Fromm, J. R., & Naresh, K. N. (2023). MEF2B is the ideal immunohistochemical marker to highlight neoplastic LP cells in nodular lymphocyte‐predominant Hodgkin lymphoma. EJHaem, 4(2), 517.

Zia, A., & Rashid, S. (2021). Systematic transition modeling analysis in the MEF2B-DNA binding interface due to Y69H and K4E variants. Journal of Molecular Graphics and Modelling, 108, 108009.

Zhong, X., Wang, T., Xie, Y., Wang, M., Zhang, W., Dai, L., ... & Wang, H. (2021). Activated protein C ameliorates diabetic cardiomyopathy via modulating OTUB1/YB-1/MEF2B axis. Frontiers in Cardiovascular Medicine, 8, 758158.

Cheng, J., Zhang, X., Li, F., Yuan, L., Zhang, D., Zhang, Y., ... & Wang, W. (2021). Detecting single nucleotide polymorphisms in MEF2B and UCP3 and elucidating their association with sheep growth traits. DNA and cell biology, 40(12), 1554-1562.

Magistri, M., Happ, L. E., Ramdial, J., Lu, X., Stathias, V., Kunkalla, K., ... & Lossos, I. S. (2021). The genetic landscape of ocular adnexa MALT lymphoma reveals frequent aberrations in NFAT and MEF2B signaling pathways. Cancer research communications, 1(1), 1.

Salama, A., Marcellino, B. K., Saad, A. G., Teruya-Feldstein, J., Firpo-Betancourt, A., Abulsayen, H. A., ... & El Jamal, S. M. (2020). Correlation analysis between the expression of MEF2B, and germinal center and nongerminal center markers in diffuse large B-cell lymphoma. Applied Immunohistochemistry & Molecular Morphology, 28(7), e63-e64.

Schmitt, R. E., Shell, B. C., Lee, K. M., Shelton, K. L., Mathies, L. D., Edwards, A. C., & Grotewiel, M. (2019). Convergent evidence from humans and Drosophila melanogaster implicates the transcription factor MEF2B/Mef2 in alcohol sensitivity. Alcoholism: Clinical and Experimental Research, 43(9), 1872-1886.

El Jamal, S. M., Grada, Z., El Dinali, M. H., Zhou, H., Hassan, S. Y., Saad, A. G., ... & Hassan, M. (2019). MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type. Laboratory Investigation, 99(4), 539-550.

Hellmuth, J. C., Chu, C. S., Singh, R., Skrabanek, L. A., Doane, A., Elemento, O., ... & Melnick, A. (2019). An OCT2/OCA-B/MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells. Blood, 134, 24.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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