Rat Anti-METRNL Recombinant Antibody (CBFYM-0214) (CBMAB-M0257-FY)

Name: Rat Anti-METRNL Recombinant Antibody (CBFYM-0214)
SKU: CBMAB-M0257-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYM-0214

Application

Specificity

Mouse

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

METEORIN LIKE, GLIAL CELL DIFFERENTIATION REGULATOR

Introduction

METRNL is a Protein Coding gene. Gene Ontology annotations related to this gene include hormone activity. An important paralog of this gene is METRN.

Entrez Gene ID

284207

UniProt ID

Q641Q3

Alternative Names

Meteorin Like, Glial Cell Differentiation Regulator; Subfatin; Meteorin, Glial Cell Differentiation Regulator-Like; Meteorin-Like Protein

Function

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

Biological Process

Brown fat cell differentiation Source: UniProtKB
Energy homeostasis Source: UniProtKB
Fat cell differentiation Source: CAFA
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of brown fat cell differentiation Source: UniProtKB
Response to cold Source: UniProtKB
Response to muscle activity Source: UniProtKB

Cellular Location

Secreted

Alizadeh, H. (2022). Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator. Cytokine, 157, 155952.

Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022). Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile. Frontiers in Endocrinology, 13, 938341.

Alizadeh, H. (2021). Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl). Growth Factors, 39(1-6), 71-78.

Schmid, A., Karrasch, T., & Schäffler, A. (2021). Meteorin-like protein (Metrnl) in obesity, during weight loss and in adipocyte differentiation. Journal of Clinical Medicine, 10(19), 4338.

Miao, Z. W., Hu, W. J., Li, Z. Y., & Miao, C. Y. (2020). Involvement of the secreted protein Metrnl in human diseases. Acta Pharmacologica Sinica, 41(12), 1525-1530.

Lee, J. O., Byun, W. S., Kang, M. J., Han, J. A., Moon, J., Shin, M. J., ... & Kim, H. S. (2020). The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2. The FEBS Journal, 287(10), 2087-2104.

Qi, Q., Hu, W. J., Zheng, S. L., Zhang, S. L., Le, Y. Y., Li, Z. Y., & Miao, C. Y. (2020). Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride. Acta Pharmacologica Sinica, 41(12), 1568-1575.

Zhang, S. L., Li, Z. Y., Wang, D. S., Xu, T. Y., Fan, M. B., Cheng, M. H., & Miao, C. Y. (2020). Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells. Acta Pharmacologica Sinica, 41(6), 763-770.

Liu, Z. X., Ji, H. H., Yao, M. P., Wang, L., Wang, Y., Zhou, P., ... & Lu, X. (2019). Serum Metrnl is associated with the presence and severity of coronary artery disease. Journal of cellular and molecular medicine, 23(1), 271-280.

Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., ... & Sun, Y. (2019). Serum levels of meteorin-like (Metrnl) are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance. Medical science monitor: international medical journal of experimental and clinical research, 25, 2337.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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