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Rat Anti-METRNL Recombinant Antibody (CBFYM-0214) (CBMAB-M0257-FY)

This product is rat antibody that recognizes METRNL. The antibody CBFYM-0214 can be used for immunoassay techniques such as: FC.
See all METRNL antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYM-0214
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
METEORIN LIKE, GLIAL CELL DIFFERENTIATION REGULATOR
Introduction
METRNL is a Protein Coding gene. Gene Ontology annotations related to this gene include hormone activity. An important paralog of this gene is METRN.
Entrez Gene ID
284207
UniProt ID
Q641Q3
Alternative Names
Meteorin Like, Glial Cell Differentiation Regulator; Subfatin; Meteorin, Glial Cell Differentiation Regulator-Like; Meteorin-Like Protein
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Biological Process
Brown fat cell differentiation Source: UniProtKB
Energy homeostasis Source: UniProtKB
Fat cell differentiation Source: CAFA
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of brown fat cell differentiation Source: UniProtKB
Response to cold Source: UniProtKB
Response to muscle activity Source: UniProtKB
Cellular Location
Secreted

Alizadeh, H. (2022). Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator. Cytokine, 157, 155952.

Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022). Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile. Frontiers in Endocrinology, 13, 938341.

Alizadeh, H. (2021). Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl). Growth Factors, 39(1-6), 71-78.

Schmid, A., Karrasch, T., & Schäffler, A. (2021). Meteorin-like protein (Metrnl) in obesity, during weight loss and in adipocyte differentiation. Journal of Clinical Medicine, 10(19), 4338.

Miao, Z. W., Hu, W. J., Li, Z. Y., & Miao, C. Y. (2020). Involvement of the secreted protein Metrnl in human diseases. Acta Pharmacologica Sinica, 41(12), 1525-1530.

Lee, J. O., Byun, W. S., Kang, M. J., Han, J. A., Moon, J., Shin, M. J., ... & Kim, H. S. (2020). The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2. The FEBS Journal, 287(10), 2087-2104.

Qi, Q., Hu, W. J., Zheng, S. L., Zhang, S. L., Le, Y. Y., Li, Z. Y., & Miao, C. Y. (2020). Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride. Acta Pharmacologica Sinica, 41(12), 1568-1575.

Zhang, S. L., Li, Z. Y., Wang, D. S., Xu, T. Y., Fan, M. B., Cheng, M. H., & Miao, C. Y. (2020). Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells. Acta Pharmacologica Sinica, 41(6), 763-770.

Liu, Z. X., Ji, H. H., Yao, M. P., Wang, L., Wang, Y., Zhou, P., ... & Lu, X. (2019). Serum Metrnl is associated with the presence and severity of coronary artery disease. Journal of cellular and molecular medicine, 23(1), 271-280.

Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., ... & Sun, Y. (2019). Serum levels of meteorin-like (Metrnl) are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance. Medical science monitor: international medical journal of experimental and clinical research, 25, 2337.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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