Mouse Metrnl ELISA Kit (V2LY-0626-LY2654)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0099 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
34.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
METEORIN LIKE, GLIAL CELL DIFFERENTIATION REGULATOR
Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).
Biological Process
Brown fat cell differentiation Source: UniProtKB
Energy homeostasis Source: UniProtKB
Fat cell differentiation Source: CAFA
Negative regulation of inflammatory response Source: UniProtKB
Positive regulation of brown fat cell differentiation Source: UniProtKB
Response to cold Source: UniProtKB
Response to muscle activity Source: UniProtKB
Cellular Location
Secreted

Alizadeh, H. (2022). Meteorin-like protein (Metrnl): A metabolic syndrome biomarker and an exercise mediator. Cytokine, 157, 155952.

Ding, X., Chang, X., Wang, J., Bian, N., An, Y., Wang, G., & Liu, J. (2022). Serum Metrnl levels are decreased in subjects with overweight or obesity and are independently associated with adverse lipid profile. Frontiers in Endocrinology, 13, 938341.

Alizadeh, H. (2021). Myokine-mediated exercise effects: the role of myokine meteorin-like hormone (Metrnl). Growth Factors, 39(1-6), 71-78.

Schmid, A., Karrasch, T., & Schäffler, A. (2021). Meteorin-like protein (Metrnl) in obesity, during weight loss and in adipocyte differentiation. Journal of Clinical Medicine, 10(19), 4338.

Miao, Z. W., Hu, W. J., Li, Z. Y., & Miao, C. Y. (2020). Involvement of the secreted protein Metrnl in human diseases. Acta Pharmacologica Sinica, 41(12), 1525-1530.

Lee, J. O., Byun, W. S., Kang, M. J., Han, J. A., Moon, J., Shin, M. J., ... & Kim, H. S. (2020). The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2. The FEBS Journal, 287(10), 2087-2104.

Qi, Q., Hu, W. J., Zheng, S. L., Zhang, S. L., Le, Y. Y., Li, Z. Y., & Miao, C. Y. (2020). Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride. Acta Pharmacologica Sinica, 41(12), 1568-1575.

Zhang, S. L., Li, Z. Y., Wang, D. S., Xu, T. Y., Fan, M. B., Cheng, M. H., & Miao, C. Y. (2020). Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells. Acta Pharmacologica Sinica, 41(6), 763-770.

Liu, Z. X., Ji, H. H., Yao, M. P., Wang, L., Wang, Y., Zhou, P., ... & Lu, X. (2019). Serum Metrnl is associated with the presence and severity of coronary artery disease. Journal of cellular and molecular medicine, 23(1), 271-280.

Wang, K., Li, F., Wang, C., Deng, Y., Cao, Z., Cui, Y., ... & Sun, Y. (2019). Serum levels of meteorin-like (Metrnl) are increased in patients with newly diagnosed type 2 diabetes mellitus and are associated with insulin resistance. Medical science monitor: international medical journal of experimental and clinical research, 25, 2337.

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For research use only. Not intended for any clinical use.

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