Mouse Anti-METTL2A Recombinant Antibody (CBFYM-0627) (CBMAB-M0762-FY)

This product is mouse antibody that recognizes METTL2A. The antibody CBFYM-0627 can be used for immunoassay techniques such as: ELISA, WB.
See all METTL2A antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYM-0627

Antibody Isotype

IgG2a, k

Application

ELISA, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, k

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

METHYLTRANSFERASE LIKE 2A

Introduction

METTL2A is a Protein Coding gene. Gene Ontology annotations related to this gene include methyltransferase activity and tRNA methyltransferase activity. An important paralog of this gene is METTL2B.

Entrez Gene ID

339175

UniProt ID

Q96IZ6

Alternative Names

Methyltransferase Like 2A; METTL2; Methyltransferase-Like Protein 2A; EC 2.1.1.-

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).

N3-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).

Biological Process

tRNA methylation Source: UniProtKB

Cellular Location

Cytoplasm

References

Wang, S., Li, H., Liu, J., Zhang, Q., Xu, W., Xiang, J., ... & Li, Z. (2022). Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer. Journal of Translational Medicine, 20(1), 1-16.

Mao, X. L., Li, Z. H., Huang, M. H., Wang, J. T., Zhou, J. B., Li, Q. R., ... & Zhou, X. L. (2021). Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. Nucleic Acids Research, 49(14), 8309-8323.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Datasheet
SDS
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