Human Recombinant METTL2A protein, GST Tag (V2LY-0526-LY5569)

Name: Human Recombinant METTL2A protein, GST Tag
SKU: V2LY-0526-LY5569
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant METTL2A protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 69 kDa.

Molecule Mass

69 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

METHYLTRANSFERASE LIKE 2A

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).

N3-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).

Biological Process

tRNA methylation Source: UniProtKB

Cellular Location

Cytoplasm

Wang, S., Li, H., Liu, J., Zhang, Q., Xu, W., Xiang, J., ... & Li, Z. (2022). Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer. Journal of Translational Medicine, 20(1), 1-16.

Mao, X. L., Li, Z. H., Huang, M. H., Wang, J. T., Zhou, J. B., Li, Q. R., ... & Zhou, X. L. (2021). Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. Nucleic Acids Research, 49(14), 8309-8323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-METTL2A Recombinant Antibody (CBFYM-0627) (CAT#: CBMAB-M0762-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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