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Mouse Anti-MFF Recombinant Antibody (CBFYM-2142) (CBMAB-M2324-FY)

This product is mouse antibody that recognizes MFF. The antibody CBFYM-2142 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all MFF antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYM-2142
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Mitochondrial Fission Factor
Introduction
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human56947
Mouse75734
Rat301563
UniProt ID
HumanQ9GZY8
MouseQ6PCP5
RatQ4KM98
Alternative Names
Mitochondrial Fission Factor; C2orf33; Chromosome 2 Open Reading Frame 33; EMPF2; GL004
Function
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Biological Process
Mitochondrial fission Source: UniProtKB
Mitochondrial fragmentation involved in apoptotic process Source: UniProtKB
Mitochondrial fusion Source: UniProtKB
Mitochondrion morphogenesis Source: MGI
Peroxisome fission Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Positive regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: UniProtKB
Protein targeting to mitochondrion Source: UniProtKB
Regulation of mitochondrion organization Source: UniProtKB
Regulation of peroxisome organization Source: UniProtKB
Release of cytochrome c from mitochondria Source: UniProtKB
Cellular Location
Peroxisome
Mitochondrion
Mitochondrion outer membrane
Other locations
synaptic vesicle
Involvement in disease
Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2):
An autosomal recessive disorder characterized by delayed psychomotor development, severe hypotonia with inability to walk, microcephaly, and abnormal signals in the basal ganglia. More variable features include early-onset seizures, optic atrophy, and peripheral neuropathy.
Topology
Cytoplasmic: 1-322
Helical: 323-340
Mitochondrial intermembrane: 341-342

Hua, R., Hai, Z., Gu, J., Guo, C., Xiao, Y., Zhao, P., ... & Wang, T. (2023). O-244 Mitochondrial fission factor (MFF) is required for female fertility and oocyte development. Human Reproduction, 38(Supplement_1), dead093-298.

Christen, M., Gutierrez‐Quintana, R., Vandenberghe, H., Kaczmarska, A., Penderis, J., José‐López, R., ... & Leeb, T. (2022). Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy. Animal genetics, 53(6), 814-820.

Schrader, T. A., Carmichael, R. E., Islinger, M., Costello, J. L., Hacker, C., Bonekamp, N. A., ... & Schrader, M. (2022). PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. Journal of Cell Science, 135(13), jcs259924.

Li, X., Wu, Q., Ma, F., Zhang, X., Cai, L., & Yang, X. (2022). Mitochondrial fission factor promotes cisplatin resistancein hepatocellular carcinoma: Mff promotes cisplatin resistance in HCC. Acta Biochimica et Biophysica Sinica, 54(3), 301.

Varuzhanyan, G., Chen, H., Rojansky, R., Ladinsky, M. S., McCaffery, J. M., & Chan, D. C. (2021). Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids. Biochimica et Biophysica Acta (BBA)-General Subjects, 1865(5), 129845.

Liu, Y., Gokhale, S., Jung, J., Zhu, S., Luo, C., Saha, D., ... & Xie, P. (2021). Mitochondrial fission factor is a novel interacting protein of the critical B cell survival regulator TRAF3 in B lymphocytes. Frontiers in Immunology, 12, 670338.

Passmore, J. B., Carmichael, R. E., Schrader, T. A., Godinho, L. F., Ferdinandusse, S., Lismont, C., ... & Schrader, M. (2020). Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1867(7), 118709.

Sánchez-Alvarez, R., De Francesco, E. M., Fiorillo, M., Sotgia, F., & Lisanti, M. P. (2020). Mitochondrial fission factor (MFF) inhibits mitochondrial metabolism and reduces breast cancer stem cell (CSC) activity. Frontiers in Oncology, 10, 1776.

Lee, L., Seager, R., Nakamura, Y., Wilkinson, K. A., & Henley, J. M. (2019). Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). PLoS One, 14(5), e0213116.

Seo, J. H., Agarwal, E., Chae, Y. C., Lee, Y. G., Garlick, D. S., Storaci, A. M., ... & Altieri, D. C. (2019). Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer. EBioMedicine, 48, 353-363.

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For research use only. Not intended for any clinical use.

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