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Mouse Anti-MFNG (AA 214-291) Recombinant Antibody (CBFYM-2158) (CBMAB-M2340-FY)

This product is mouse antibody that recognizes MFNG. The antibody CBFYM-2158 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB-Re.
See all MFNG antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2158
Antibody Isotype
IgG2a, k
Application
S-ELISA, ELISA, WB-Re

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 214-291

Target

Full Name
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Introduction
This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.
Entrez Gene ID
4242
UniProt ID
O00587
Alternative Names
MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; EC 2.4.1.222; O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase; Manic Fringe (Drosophila) Homolog; Manic Fringe Homolog (Drosophila)
Function
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626).

Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).
Biological Process
Blastocyst formation Source: Ensembl
Marginal zone B cell differentiation Source: UniProtKB
Pattern specification process Source: ProtInc
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Regulation of Notch signaling pathway Source: UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7
Helical: 8-27
Lumenal: 28-321
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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