MFNG

This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. [provided by RefSeq]

Full Name

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Function

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626).

Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity).

Biological Process

Blastocyst formation Source: Ensembl
Marginal zone B cell differentiation Source: UniProtKB
Pattern specification process Source: ProtInc
Positive regulation of Notch signaling pathway Source: Ensembl
Positive regulation of protein binding Source: Ensembl
Regulation of Notch signaling pathway Source: UniProtKB

Cellular Location

Golgi apparatus membrane

Topology

Cytoplasmic: 1-7
Helical: 8-27
Lumenal: 28-321