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Mouse Anti-MGST2 Recombinant Antibody (4E1) (CBMAB-A5474-LY)

The product is antibody recognizes MGST2. The antibody 4E1 immunoassay techniques such as: IP, ELISA.
See all MGST2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4E1
Antibody Isotype
IgG2a, κ
Application
IP, ELISA

Basic Information

Immunogen
MGST2 (AAH25416, 1 a.a. ~ 147 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
microsomal glutathione S-transferase 2
Introduction
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. [provided by RefSeq]
Entrez Gene ID
4258
UniProt ID
Q99735
Alternative Names
FLJ27438; GST2; MGC14097; MGST-II
Function
Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610).

Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838).

Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034).

Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251).

Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).
Biological Process
Glutathione biosynthetic process Source: UniProtKB
Leukotriene biosynthetic process Source: UniProtKB
Lipid metabolic process Source: BHF-UCL
Membrane lipid catabolic process Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL
Cellular Location
Endoplasmic reticulum
Endoplasmic reticulum membrane
Microsome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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