Mouse Anti-MGST2 (AA 1-147) Recombinant Antibody (CBFYM-2193) (CBMAB-M2375-FY)

Name: Mouse Anti-MGST2 (AA 1-147) Recombinant Antibody (CBFYM-2193)
SKU: CBMAB-M2375-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2193

Application

ELISA, IP

Immunogen

Full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAGNSILLAA VSILSACQQS YFALQVGKAR LKYKVTPPAV TGSPEFERVF RAQQNCVEFY PIFIITLWMA GWYFNQVFAT CLGLVYIYGR HLYFWGYSEA AKKRITGFRL SLGILALLTL LGALGIANSF LDEYLDLNIA K

Specificity

Human

Antibody Isotype

IgG2b, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-147

More Infomation

Target

Full Name

microsomal glutathione S-transferase 2

Introduction

The MAPEG family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Entrez Gene ID

4258

UniProt ID

Q99735

Alternative Names

Microsomal Glutathione S-Transferase 2; Microsomal GST-II; Microsomal GST-2; GST2; EC 2.5.1.18; MGST-II

Function

Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610).

Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838).

Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034).

Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251).

Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).

Biological Process

Glutathione biosynthetic process Source: UniProtKB
Leukotriene biosynthetic process Source: UniProtKB
Lipid metabolic process Source: BHF-UCL
Membrane lipid catabolic process Source: BHF-UCL
Positive regulation of inflammatory response Source: BHF-UCL

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Microsome membrane

Thulasingam, M., Orellana, L., Nji, E., Ahmad, S., Rinaldo-Matthis, A., & Haeggström, J. Z. (2021). Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis. Nature Communications, 12(1), 1728.

Zhao, G., Zhao, W., Cui, X., Xu, B., Liu, Q., Li, H., & Guo, X. (2021). Identification of an MGST2 gene and analysis of its function in antioxidant processes in Apis cerana cerana. Archives of Insect Biochemistry and Physiology, 106(4), e21770.

Lai, M. W., Liang, K. H., & Yeh, C. T. (2020). Hepatitis B virus preS/S truncation mutant rtM204I/sW196* increases carcinogenesis through deregulated HIF1A, MGST2, and TGFbi. International Journal of Molecular Sciences, 21(17), 6366.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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