Mouse Anti-MGST3 Recombinant Antibody (2G10CG7) (CBMAB-M2377-FY)

Name: Mouse Anti-MGST3 Recombinant Antibody (2G10CG7)
SKU: CBMAB-M2377-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G10CG7

Application

IP, IF, ELISA

Specificity

Rat, Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

>95% by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

microsomal glutathione S-transferase 3

Introduction

This gene encodes a member of the MAPEG protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.

Entrez Gene ID

Human	4259
Rat	289197

UniProt ID

Human	O14880
Rat	D4ADS4

Alternative Names

Microsomal Glutathione S-Transferase 3; Microsomal GST-III; Microsomal GST-3; Microsomal Glutathione S-Transferase III; EC 2.5.1.18; GST-III

Function

Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457).

Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457).

May participate in the lipid metabolism (PubMed:9278457).

Biological Process

Leukotriene biosynthetic process Source: BHF-UCL
Lipid metabolic process Source: BHF-UCL

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Microsome membrane
Other locations
Membrane

Yan, J., Zhang, H., Tomochika, Y., Chen, B., Ping, Y., Islam, M. S., ... & Setou, M. (2023). UBL3 interaction with α-synuclein is downregulated by silencing MGST3. Biomedicines, 11(9), 2491.

Steinmetz-Späh, J., Liu, J., Singh, R., Ekoff, M., Boddul, S., Tang, X., ... & Jakobsson, P. J. (2022). Biosynthesis of prostaglandin 15dPGJ2-glutathione and 15dPGJ2-cysteine conjugates in macrophages and mast cells via MGST3. Journal of Lipid Research, 63(12).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-MGST3 (AA 1-152) Recombinant Antibody (CBFYM-2194) (CAT#: CBMAB-M2376-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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